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Open AccessArticle

The Differences in Postprandial Serum Concentrations of Peptides That Regulate Satiety/Hunger and Metabolism after Various Meal Intake, in Men with Normal vs. Excessive BMI

1
Clinical Research Centre, Medical University of Bialystok, MC Sklodowskiej 24A, 15-276 Bialystok, Poland
2
Department of Dietetics and Clinical Nutrition, Medical University of Bialystok, Mieszka I-go 4B, 15-054 Bialystok, Poland
3
Department of Endocrinology, Diabetology and Internal Medicine, Medical University of Bialystok, MC Sklodowskiej 24A, 15-276 Bialystok, Poland
*
Author to whom correspondence should be addressed.
Nutrients 2019, 11(3), 493; https://doi.org/10.3390/nu11030493
Received: 25 January 2019 / Revised: 13 February 2019 / Accepted: 22 February 2019 / Published: 26 February 2019
(This article belongs to the Special Issue Personalized Nutrition-1)
The energy balance regulation may differ in lean and obese people. The purposes of our study were to evaluate the hormonal response to meals with varying macronutrient content, and the differences depending on body weight. Methods. The crossover study included 46 men, 21–58 years old, normal-weight and overweight/obese. Every subject participated in two meal-challenge-tests with high-carbohydrate (HC), and normo-carbohydrate (NC) or high-fat (HF) meals. Fasting and postprandial blood was collected for a further 240 min, to determine adiponectin, leptin and total ghrelin concentrations. Results. In normal-weight individuals after HC-meal we observed at 60min higher adiponectin concentrations (12,554 ± 1531 vs. 8691 ± 1070 ng/mL, p = 0.01) and significantly (p < 0.05) lower total ghrelin concentrations during the first 120 min, than after HF-meal intake. Fasting and postprandial leptin levels were significantly (p < 0.05) higher in overweigh/obese men. Leptin concentrations in normal-weight men were higher (2.72 ± 0.8 vs. 1.56 ± 0.4 ng/mL, p = 0.01) 180 min after HC-meal than after NC-meal intake. Conclusions. Our results suggest that in normal-body weight men we can expect more beneficial leptin, adiponectin, and total ghrelin response after HC-meal intake, whereas, in overweight/obese men, the HC-meal intake may exacerbate the feeling of hunger, and satiety may be induced more by meals with lower carbohydrate content. View Full-Text
Keywords: obesity; postprandial adiponectin; postprandial leptin; postprandial total ghrelin; high-carbohydrate meal; high-fat meal obesity; postprandial adiponectin; postprandial leptin; postprandial total ghrelin; high-carbohydrate meal; high-fat meal
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Adamska-Patruno, E.; Ostrowska, L.; Goscik, J.; Fiedorczuk, J.; Moroz, M.; Kretowski, A.; Gorska, M. The Differences in Postprandial Serum Concentrations of Peptides That Regulate Satiety/Hunger and Metabolism after Various Meal Intake, in Men with Normal vs. Excessive BMI. Nutrients 2019, 11, 493.

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