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Open AccessArticle

Hypoglycemic and Hypolipidemic Effects of Phellinus Linteus Mycelial Extract from Solid-State Culture in A Rat Model of Type 2 Diabetes

1
State Key Laboratory of Agricultural Microbiology, College of Life Science and Technology, Huazhong Agricultural University, Wuhan 430070, China
2
Department of Chemistry, University of California, Davis, CA 95616, USA
*
Author to whom correspondence should be addressed.
Nutrients 2019, 11(2), 296; https://doi.org/10.3390/nu11020296
Received: 26 December 2018 / Revised: 16 January 2019 / Accepted: 25 January 2019 / Published: 30 January 2019
Hypoglycemic and hypolipidemic effects of P. linteus have been observed in numerous studies, but the underlying molecular mechanisms are unclear. In this study, we prepared P. linteus extract (PLE) from mycelia of solid-state culture, and evaluated its hypoglycemic and hypolipidemic effects in rat models of high-fat diet (HFD)-induced and low-dose streptozotocin (STZ)-induced type 2 diabetes. PLE treatment effectively reduced blood glucose levels, and improved insulin resistance and lipid and lipoprotein profiles. The hypoglycemic effect of PLE was based on inhibition of key hepatic gluconeogenesis enzymes (FBPase, G6Pase) expression and hepatic glycogen degradation, and consequent reduction of hepatic glucose production. PLE also: (i) enhanced expression of CPT1A and ACOX1 (key proteins involved in fatty acid β-oxidation) and low-density lipoprotein receptor (LDLR) in liver, thus promoting clearance of triglycerides and LDL-C; (ii) inhibited expression of 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR) in liver, thus reducing cholesterol production; (iii) displayed strong hepatoprotective and renal protective effects. Our findings indicate that PLE has strong potential functional food application in adjuvant treatment of type 2 diabetes with dyslipidemia. View Full-Text
Keywords: Phellinus linteus extract; type 2 diabetes; hypoglycemic effect; hypolipidemic effect Phellinus linteus extract; type 2 diabetes; hypoglycemic effect; hypolipidemic effect
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MDPI and ACS Style

Liu, Y.; Wang, C.; Li, J.; Mei, Y.; Liang, Y. Hypoglycemic and Hypolipidemic Effects of Phellinus Linteus Mycelial Extract from Solid-State Culture in A Rat Model of Type 2 Diabetes. Nutrients 2019, 11, 296. https://doi.org/10.3390/nu11020296

AMA Style

Liu Y, Wang C, Li J, Mei Y, Liang Y. Hypoglycemic and Hypolipidemic Effects of Phellinus Linteus Mycelial Extract from Solid-State Culture in A Rat Model of Type 2 Diabetes. Nutrients. 2019; 11(2):296. https://doi.org/10.3390/nu11020296

Chicago/Turabian Style

Liu, Yangyang; Wang, Chaorui; Li, Jinshan; Mei, Yuxia; Liang, Yunxiang. 2019. "Hypoglycemic and Hypolipidemic Effects of Phellinus Linteus Mycelial Extract from Solid-State Culture in A Rat Model of Type 2 Diabetes" Nutrients 11, no. 2: 296. https://doi.org/10.3390/nu11020296

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