Nutrients 2019, 11(2), 217; https://doi.org/10.3390/nu11020217
Impact of Grain Sorghum Polyphenols on Microbiota of Normal Weight and Overweight/Obese Subjects during In Vitro Fecal Fermentation
Danielle Ashley 1, Daya Marasini 1
, Cindi Brownmiller 1, Jung Ae Lee 2, Franck Carbonero 1 and Sun-Ok Lee 1,*
, Cindi Brownmiller 1, Jung Ae Lee 2, Franck Carbonero 1 and Sun-Ok Lee 1,*
1
Department of Food Science, Division of Agriculture, University of Arkansas, Fayetteville, AR 72704, USA
2
Agricultural Statistics Laboratory, Division of Agriculture, University of Arkansas, Fayetteville, AR 72704, USA
*
Author to whom correspondence should be addressed.
Received: 30 October 2018 / Revised: 7 January 2019 / Accepted: 14 January 2019 / Published: 22 January 2019
Abstract
The human gut microbiota is considered as a crucial mediator between diet and gut homeostasis and body weight. The unique polyphenolic profile of sorghum bran may promote gastrointestinal health by modulating the microbiota. This study evaluated gut microbiota and modulation of short-chain fatty acids (SCFA) by sorghum bran polyphenols in in vitro batch fermentation derived from normal weight (NW, n = 11) and overweight/obese (OO, n = 11) subjects’ fecal samples. Six separate treatments were applied on each batch fermentation: negative control (NC), fructooligosaccharides (FOS), black sorghum bran extract (BSE), sumac sorghum bran extract (SSE), FOS + BSE, or FOS + SSE; and samples were collected before and after 24 h. No significant differences in total and individual SCFA production were observed between NW and OO subjects. Differential responses to treatment according to weight class were observed in both phyla and genera. Sorghum bran polyphenols worked with FOS to enhance Bifidobacterium and Lactobacillus, and independently stimulated Roseburia and Prevotella (p < 0.05). Our results indicate that sorghum bran polyphenols have differential effects on gut health and may positively impact gut ecology, with responses varying depending on weight class. View Full-TextKeywords:
sorghum bran polyphenols; gut microbiota; sumac sorghum bran; black sorghum bran; short-chain fatty acids
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Ashley, D.; Marasini, D.; Brownmiller, C.; Lee, J.A.; Carbonero, F.; Lee, S.-O. Impact of Grain Sorghum Polyphenols on Microbiota of Normal Weight and Overweight/Obese Subjects during In Vitro Fecal Fermentation. Nutrients 2019, 11, 217.
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