The Effect of Macronutrients on Reproductive Hormones in Overweight and Obese Men: A Pilot Study
Round 1
Reviewer 1 Report
No more comments as the manuscript has been significantly improved.
Author Response
Thanks for your comments.
Reviewer 2 Report
In this manuscript, Pearce and Tremellen investigate how different kind of macronutrients alter the testosterone levels in faster overweight or obese fertile men. Both in normal and in hypogonadal men, the effort of protein may be beneficial in enhancing serum testosterone levels in 4-5 hours post consumption. For me, this manuscript is interesting because it provides many ideas for future studies about the correlation between nutrients and testosterone level variations and could be useful to develop new therapies to normalize the testosterone levels in men.
To my humble opinion, the biggest flaw of this study is the substitution of partecipants during the whole period. I think that also when they choose people with similar characteristics, they change the reference point. Maybe a good solution could be reduce the number of partecipants for each group, and analyze data using only people that partecipated to the whole program. The obtained data could be compared with the data showed into the manuscript and eventually validate them.
Author Response
Thanks for your comments.
