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The Effect of Antioxidant Supplementation in Patients with Tinnitus and Normal Hearing or Hearing Loss: A Randomized, Double-Blind, Placebo Controlled Trial

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1st ENT Department, School of Medicine, National and Kapodistrian University of Athens, Hippokration Hospital, 11527 Athens, Greece
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ENT Department, General Hospital of Nikaia “Agios Panteleimon”, Nikaia, 18454 Athens, Greece
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ENT Department, St. Johannes Hospital, 44137 Dortmund, Germany
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2nd ENT Department, School of Medicine, National and Kapodistrian University of Athens, Attikon Hospital, 12462 Chaidari, Greece
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Department of Biology, School of Medicine, National and Kapodistrian University of Athens, 11527 Athens, Greece
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Department of Dietetics and Nutritional Science, School of Health Science and Education, Harokopio University, 17671 Athens, Greece
*
Author to whom correspondence should be addressed.
Nutrients 2019, 11(12), 3037; https://doi.org/10.3390/nu11123037
Received: 7 November 2019 / Revised: 27 November 2019 / Accepted: 3 December 2019 / Published: 12 December 2019
(This article belongs to the Special Issue Dietary Supplements and Human Health)
Tinnitus is the perception of sound in the absence of any external stimulus. Oxidative stress is possibly involved in its pathogenesis and a variety of antioxidant compounds have been studied as potential treatment approaches. The objective of the present study was to assess the effects of antioxidant supplementation in tinnitus patients. This is a randomized, double-blind, placebo-controlled clinical trial. Patients (N = 70) were randomly allocated to antioxidant supplementation (N = 35) or to placebo (N = 35) for a total of 3 months. Demographic, anthropometric, clinical, and nutritional data were collected. Serum total antioxidant capacity (TAC), oxidized LDL (oxLDL), and superoxide dismutase (SOD), tinnitus loudness, frequency, and minimum masking level (MML), and scores in Tinnitus Handicap Inventory questionnaire (THI), Tinnitus Functional Index (TFI), and Visual Analogue Scale (VAS) were evaluated at baseline and follow-up. Tinnitus loudness and MML significantly decreased from baseline to post measure (p < 0.001) only in the antioxidant group, the overall change being significantly different between the two groups post-intervention (p < 0.001). THI and VAS decreased only in the antioxidant group. Differences in changes in serum TAC, SOD, and oxLDL post-intervention were insignificant. In conclusion, antioxidant therapy seems to reduce the subjective discomfort and tinnitus intensity in tinnitus patients. View Full-Text
Keywords: tinnitus; antioxidant supplementation; oxidative stress; a-lipoic acid; multi-vitamin supplement tinnitus; antioxidant supplementation; oxidative stress; a-lipoic acid; multi-vitamin supplement
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Petridou, A.I.; Zagora, E.T.; Petridis, P.; Korres, G.S.; Gazouli, M.; Xenelis, I.; Kyrodimos, E.; Kontothanasi, G.; Kaliora, A.C. The Effect of Antioxidant Supplementation in Patients with Tinnitus and Normal Hearing or Hearing Loss: A Randomized, Double-Blind, Placebo Controlled Trial. Nutrients 2019, 11, 3037.

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