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Obesity in the Liver Transplant Setting
Open AccessArticle

Weight Gain and De Novo Metabolic Disorders after Liver Transplantation

Department of Translational and Precision medicine, Sapienza University of Rome, Italy Viale dell’Università 37, 00185 Roma, Italy
Department of General Surgery “Paride Stefanini”, Liver Transplantation Unit, “Sapienza” University, 00185 Rome, Italy
Author to whom correspondence should be addressed.
Nutrients 2019, 11(12), 3015;
Received: 11 November 2019 / Revised: 30 November 2019 / Accepted: 5 December 2019 / Published: 10 December 2019
(This article belongs to the Special Issue Nutrition in Liver Cirrhosis and Liver Transplantation)
The development of nutritional and metabolic abnormalities represents an important burden in patients after liver transplantation (LT). Our study aimed at evaluating the incidence, time of onset, and risk factors for nutritional and metabolic abnormalities in patients after LT. The study was a single-center retrospective study. Consecutive patients undergoing elective LT from 2000 to 2016 were enrolled. The presence of at least two among arterial hypertension (AH), diabetes mellitus (DM), dyslipidemia, and obesity (BMI ≥ 30 Kg/m2) was utilized to define patients with the metabolic disorder (MD). Three hundred and fifteen patients were enrolled; the median age was 56 years (68% males). Non-alcoholic steatohepatitis (NASH) was the origin of liver disease in 10% of patients. During follow-up, 39% of patients developed AH, 18% DM, and 17% dyslipidemia. Metabolic disorders were observed in 32% of patients. The NASH etiology (OR: 6.2; CI 95% 0.5–3; p = 0.003) and a longer follow-up (OR: 1.2; CI 95% 0.004–0.02; p = 0.002) were associated with de novo MD. In conclusion, nutritional and metabolic disorders are a frequent complication after LT, being present in up to one-third of patients. The NASH etiology and a longer distance from LT are associated with de novo MD after LT. View Full-Text
Keywords: liver transplantation (LT); body mass index (BMI); metabolic disorders (MDs), non-alcoholic steatohepatitis (NASH) liver transplantation (LT); body mass index (BMI); metabolic disorders (MDs), non-alcoholic steatohepatitis (NASH)
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Lattanzi, B.; D’Ambrosio, D.; Tavano, D.; Pitoni, D.; Mennini, G.; Ginanni Corradini, S.; Rossi, M.; Merli, M. Weight Gain and De Novo Metabolic Disorders after Liver Transplantation. Nutrients 2019, 11, 3015.

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