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Gut Microbiota and Obesity: A Role for Probiotics

1
Department of Health Sciences, University Magna Graecia, Campus “Salvatore Venuta”, 88100 Catanzaro, Italy
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Clinical Nutrition Unit, and Internal Medicine Unit, “Madonna del Soccorso” General Hospital, Via Luciano Manara 7, 63074 San Benedetto del Tronto (AP), Italy
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CNR, IBFM UOS, Università degli Studi “Magna Graecia” di Catanzaro, Campus “Salvatore Venuta”, 88100 Catanzaro, Italy
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Greenwood Genetic Center, Greenwood, SC 29646, USA
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Clemson University School of Health Research, Clemson, SC 29634, USA
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Student Research Committee, School of Medicine, Bam University of Medical Sciences, Bam 44340847, Iran
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Zabol Medicinal Plants Research Center, Zabol University of Medical Sciences, Zabol 61615585, Iran
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Department of Medical and Surgical Sciences, University of Magna Græcia, Viale Europa, Germaneto, 88100 Catanzaro, Italy
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Department of Pharmacy, School of Medicine and Surgery, University of Naples Federico II, Via Domenico Montesano 49, 80131 Naples, Italy
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Division of Clinical Nutrition and Nutrigenomic, Department of Biomedicine and Prevention, University of Tor Vergata, Via Montpellier 1, 00133 Rome, Italy
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Department of Agricultural Sciences, University of Naples Federico II, Via Università 100, 80055 Portici (NA), Italy
*
Authors to whom correspondence should be addressed.
Nutrients 2019, 11(11), 2690; https://doi.org/10.3390/nu11112690
Received: 10 August 2019 / Revised: 23 September 2019 / Accepted: 24 September 2019 / Published: 7 November 2019
(This article belongs to the Special Issue Gut Microbiota and Malnutrition)
Nowadays, obesity is one of the most prevalent human health problems. Research from the last 30 years has clarified the role of the imbalance between energy intake and expenditure, unhealthy lifestyle, and genetic variability in the development of obesity. More recently, the composition and metabolic functions of gut microbiota have been proposed as being able to affect obesity development. Here, we will report the current knowledge on the definition, composition, and functions of intestinal microbiota. We have performed an extensive review of the literature, searching for the following keywords: metabolism, gut microbiota, dysbiosis, obesity. There is evidence for the association between gut bacteria and obesity both in infancy and in adults. There are several genetic, metabolic, and inflammatory pathophysiological mechanisms involved in the interplay between gut microbes and obesity. Microbial changes in the human gut can be considered a factor involved in obesity development in humans. The modulation of the bacterial strains in the digestive tract can help to reshape the metabolic profile in the human obese host as suggested by several data from animal and human studies. Thus, a deep revision of the evidence pertaining to the use probiotics, prebiotics, and antibiotics in obese patients is conceivable View Full-Text
Keywords: metabolism; gut microbiota; dysbiosis; obesity metabolism; gut microbiota; dysbiosis; obesity
MDPI and ACS Style

Abenavoli, L.; Scarpellini, E.; Colica, C.; Boccuto, L.; Salehi, B.; Sharifi-Rad, J.; Aiello, V.; Romano, B.; De Lorenzo, A.; Izzo, A.A.; Capasso, R. Gut Microbiota and Obesity: A Role for Probiotics. Nutrients 2019, 11, 2690. https://doi.org/10.3390/nu11112690

AMA Style

Abenavoli L, Scarpellini E, Colica C, Boccuto L, Salehi B, Sharifi-Rad J, Aiello V, Romano B, De Lorenzo A, Izzo AA, Capasso R. Gut Microbiota and Obesity: A Role for Probiotics. Nutrients. 2019; 11(11):2690. https://doi.org/10.3390/nu11112690

Chicago/Turabian Style

Abenavoli, Ludovico, Emidio Scarpellini, Carmela Colica, Luigi Boccuto, Bahare Salehi, Javad Sharifi-Rad, Vincenzo Aiello, Barbara Romano, Antonino De Lorenzo, Angelo A. Izzo, and Raffaele Capasso. 2019. "Gut Microbiota and Obesity: A Role for Probiotics" Nutrients 11, no. 11: 2690. https://doi.org/10.3390/nu11112690

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