Protective Effect of Green Tea Consumption on Colorectal Cancer Varies by Lifestyle Factors
by
Hyejin Kim 1, Jeonghee Lee 1, Jae Hwan Oh 2, Hee Jin Chang 2, Dae Kyung Sohn 2, Aesun Shin 3
and Jeongseon Kim 1,*
Hyejin Kim 1, Jeonghee Lee 1, Jae Hwan Oh 2, Hee Jin Chang 2, Dae Kyung Sohn 2, Aesun Shin 3 and Jeongseon Kim 1,*
1
Department of Cancer Biomedical Science, Graduate School of Cancer Science and Policy, National Cancer Center, 323, Ilsan-ro, Ilsandong-gu, Goyang-si, Gyeonggi-do 10408, Korea
2
Center for Colorectal Cancer, National Cancer Center Hospital, National Cancer Center, 323, Ilsan-ro, Ilsandong-gu, Goyang-si, Gyeonggi-do 10408, Korea
3
Department of Preventive Medicine, Seoul National University College of Medicine, 103, Deahak-ro, Jongno-gu, Seoul 03080, Korea
*
Author to whom correspondence should be addressed.
Nutrients 2019, 11(11), 2612; https://doi.org/10.3390/nu11112612
Received: 5 September 2019 / Revised: 23 October 2019 / Accepted: 23 October 2019 / Published: 1 November 2019
The inconsistent findings regarding green tea intake and colorectal cancer (CRC) risk in several epidemiological studies might result from variations in lifestyle factors. Therefore, we examined whether increased green tea intake was associated with a decreased risk of CRC and how the risk of CRC was altered by the protective effect of green tea consumption and five health-related factors. A case-control study including 2742 participants (922 cases and 1820 controls) was conducted in Korea. Green tea consumption was assessed using a semiquantitative food frequency questionnaire. The risk of CRC was approximately 40% less in the participants in the highest green tea intake tertile than in participants in the lowest green tea intake tertile. Of the five lifestyle factors examined, high body mass index and physical inactivity were independent risk factors for CRC. Regarding the interactions between tea consumption and lifestyle factors, high green tea consumption was associated with a decreased risk of CRC, with or without considering lifestyle factors. However, moderate green tea consumption increased the risk of CRC among ever-smokers, ever-drinkers and the high-inflammatory diet group. Increased consumption of green tea might be helpful to reduce the risk of CRC in those with an unhealthy lifestyle.
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Keywords:
cancer; colorectal cancer; case-control study; green tea; lifestyle factors
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MDPI and ACS Style
Kim, H.; Lee, J.; Oh, J.H.; Chang, H.J.; Sohn, D.K.; Shin, A.; Kim, J. Protective Effect of Green Tea Consumption on Colorectal Cancer Varies by Lifestyle Factors. Nutrients 2019, 11, 2612.
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