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Open AccessArticle

Effects of Periodic Fasting on Fatty Liver Index—A Prospective Observational Study

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Buchinger Wilhelmi Clinic, 88662 Überlingen, Germany
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Clinic St. Katharinental, Department of Rheumatology, 8253 Diessenhofen, Switzerland
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Charité–Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt–Universität zu Berlin and Berlin Institute of Health, 10117 Berlin, Germany
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Division of Rheumatology, Immunology and Rehabilitation, Kantonsspital St. Gallen, 9007 St. Gallen, Switzerland
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Institute of Medical Statistics, Computer Sciences and Documentation, Jena University Hospital, 07743 Jena, Germany
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Department of Internal and Complementary Medicine, Immanuel Hospital Berlin, 14109 Berlin, Germany
*
Author to whom correspondence should be addressed.
Nutrients 2019, 11(11), 2601; https://doi.org/10.3390/nu11112601
Received: 19 September 2019 / Revised: 24 October 2019 / Accepted: 28 October 2019 / Published: 30 October 2019
This prospective observational trial investigated effects and safety of periodic fasting in subjects with and without type 2 diabetes mellitus (T2DM). The primary end point was set as the change of fatty liver index (FLI) as a surrogate parameter of non-alcoholic fatty liver disease (NAFLD). Six-hundred and ninety-seven subjects (38 with T2DM) were enrolled. A baseline FLI ≥ 60 (the threshold for fatty liver) was found in 264 subjects (37.9%). The mean duration of fasting was 8.5 ± 4.0 days (range 6–38). FLI decreased significantly (−14.02 ± 11.67; p < 0.0001), with a larger effect in individuals with T2DM (−19.15 ± 11.0; p < 0.0001; p = 0.002 compared to non-diabetic subjects). Body mass index (BMI) decreased by −1.51 ± 0.82 kg/m2, and 49.9% of the subjects lost ≥5% body weight. After fasting, nearly half of the 264 subjects with FLI ≥ 60 (highest risk category) shifted to a lower category. The improvement of FLI correlated with the number of fasting days (r = −0.20, p < 0.0001) and with the magnitude of BMI reduction (r = 0.14, p = 0.0001). Periodic fasting with concomitant weight reduction leads to significant rapid improvement of FLI in subjects with and without T2DM. View Full-Text
Keywords: periodic fasting; obesity; overweight; fatty liver index; diabetes periodic fasting; obesity; overweight; fatty liver index; diabetes
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Drinda, S.; Grundler, F.; Neumann, T.; Lehmann, T.; Steckhan, N.; Michalsen, A.; Wilhelmi de Toledo, F. Effects of Periodic Fasting on Fatty Liver Index—A Prospective Observational Study. Nutrients 2019, 11, 2601.

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