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Open AccessArticle

Single Nucleotide Polymorphisms in PEMT and MTHFR Genes are Associated with Omega 3 and 6 Fatty Acid Levels in the Red Blood Cells of Children with Obesity

1
Centre of Genomic Medicine, Genetics Discipline, “Victor Babes” University of Medicine and Pharmacy, Timisoara 300041, Romania
2
The National Institute of Research and Development for Biological Sciences, Bucharest 060031, Romania
3
“Louis Turcanu” Clinical Emergency Hospital for Children, Timisoara 300011, Romania
4
Paediatrics Department, “Victor Babes” University of Medicine and Pharmacy, Timisoara 300041, Romania
5
2nd Paediatrics Clinic, Clinical Emergency County Hospital, Timisoara 300041, Romania
6
Department of Functional Sciences, ”Victor Babes” University of Medicine and Pharmacy, Timișoara 300041, Romania
7
Faculty of Automation and Computer Science, Politehnica University of Timisoara, Timisoara 300223, Romania
8
Advanced Nutrigenomics, 130 Rainbow Ct, Cary, NC 27511, USA
*
Author to whom correspondence should be addressed.
The two authors contributed equally.
Nutrients 2019, 11(11), 2600; https://doi.org/10.3390/nu11112600
Received: 10 October 2019 / Revised: 24 October 2019 / Accepted: 25 October 2019 / Published: 30 October 2019
Polyunsaturated fatty acids (PUFAs) play important roles in health and disease. PUFA levels are influenced by nutrition and genetic factors. The relationship between PUFA composition in red blood cells (RBCs) and genetic variations involved in PUFA metabolism has not been investigated in children with obesity. This study evaluated the association between several genetic variations and PUFA levels in RBCs in children with obesity. One hundred ninety-six children with obesity (101 females, 95 males) were evaluated using anthropometric measurements, dietary intakes, plasma and RBC PUFA quantification, blood biochemistry, and 55 single nucleotide polymorphisms within 14 genes. phosphatidylethanolamine N-methyltransferase (PEMT) rs1109859 and methylenetetrahydrofolate reductase gene (MTHFR) rs4846052 genotypes were associated with PUFA levels in RBCs. PUFA intake did not influence the RBC eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) levels. Higher RBC DHA and EPA levels were observed for PEMT rs1109859 GG and GA genotypes versus the AA genotype. Higher levels of RBC DHA, EPA, arachidonic acid (ARA), and linoleic acid (LA) and were observed for MTHFR rs4846052 TT genotype versus TC and CC genotypes. Genetic variations in PEMT rs1109859 and MTHFR rs4846052 were associated with different PUFA levels in RBC membranes and are estimators for PUFA species in RBCs. Further research is needed to establish whether these genotype-specific alterations are specific to overweight children. View Full-Text
Keywords: polyunsaturated fatty acids; PEMT; MTHFR; children; obesity; red blood cells polyunsaturated fatty acids; PEMT; MTHFR; children; obesity; red blood cells
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MDPI and ACS Style

Serafim, V.; Chirita-Emandi, A.; Andreescu, N.; Tiugan, D.-A.; Tutac, P.; Paul, C.; Velea, I.; Mihailescu, A.; Șerban, C.L.; Zimbru, C.G.; Puiu, M.; Niculescu, M.D. Single Nucleotide Polymorphisms in PEMT and MTHFR Genes are Associated with Omega 3 and 6 Fatty Acid Levels in the Red Blood Cells of Children with Obesity. Nutrients 2019, 11, 2600. https://doi.org/10.3390/nu11112600

AMA Style

Serafim V, Chirita-Emandi A, Andreescu N, Tiugan D-A, Tutac P, Paul C, Velea I, Mihailescu A, Șerban CL, Zimbru CG, Puiu M, Niculescu MD. Single Nucleotide Polymorphisms in PEMT and MTHFR Genes are Associated with Omega 3 and 6 Fatty Acid Levels in the Red Blood Cells of Children with Obesity. Nutrients. 2019; 11(11):2600. https://doi.org/10.3390/nu11112600

Chicago/Turabian Style

Serafim, Vlad; Chirita-Emandi, Adela; Andreescu, Nicoleta; Tiugan, Diana-Andreea; Tutac, Paul; Paul, Corina; Velea, Iulian; Mihailescu, Alexandra; Șerban, Costela L.; Zimbru, Cristian G.; Puiu, Maria; Niculescu, Mihai D. 2019. "Single Nucleotide Polymorphisms in PEMT and MTHFR Genes are Associated with Omega 3 and 6 Fatty Acid Levels in the Red Blood Cells of Children with Obesity" Nutrients 11, no. 11: 2600. https://doi.org/10.3390/nu11112600

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