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Open AccessArticle

The Association between Dietary Inflammatory Index (DII) and Cancer Risk in Korea: A Prospective Cohort Study within the KoGES-HEXA Study

1
Department of Food and Nutrition, Yonsei University, Seoul 03722, Korea
2
Division of Cancer Epidemiology and Management, National Cancer Center, Goyang-si, Gyeonggi-do 10408, Korea
3
Department of Food and Nutrition, Wonkwang University, Iksan-si, Jeollabuk-do 54538, Korea
4
Cancer Prevention and Control Program, University of South Carolina, Columbia, SC 29208, USA
5
Department of Epidemiology and Biostatistics, Arnold School of Public Health, University of South Carolina, Columbia, SC 29208, USA
6
Connecting Health Innovations LLC, Columbia, SC 29201, USA
*
Author to whom correspondence should be addressed.
Equally contributed to this work.
Nutrients 2019, 11(11), 2560; https://doi.org/10.3390/nu11112560
Received: 20 September 2019 / Revised: 16 October 2019 / Accepted: 21 October 2019 / Published: 23 October 2019
Several epidemiological studies have shown that there are consistently positive associations between dietary inflammatory index (DII®) scores and cancer incidence in Western populations. However, few DII-cancer studies have been conducted in East Asian populations. In a large cohort representative of the general Korean population, we investigated whether the DII is associated with overall cancer risk. A total of 163,660 participants (56,781 males and 106,879 females) had evaluable data for analyses. This follow-up study was carried out over the course of 7.9 years. DII scores were calculated based on Semi-Quantitative Food-Frequency Questionnaire (SQ-FFQ) data for 106 food items. Cancers were self-reported based on notification by the participants’ medical doctors. Multivariable Cox proportional hazard regression was used to estimate hazard ratios (HRs) with 95% confidence intervals (CIs). After the follow-up, 1643 incident cases of cancer (520 males and 1123 females) had developed. In a fully adjusted model, women in the highest DII quintile showed a 44% increased risk of getting cancer (HRQ5vsQ1 = 1.44; 95% CI = 1.14–1.82; p-trend = 0.0006), while men showed no apparent association (HRQ5vsQ1 = 0.80; 95% CI = 0.58–1.10). These results indicate that in Korean women, a more pro-inflammatory diet is associated with a higher risk of incident cancer. View Full-Text
Keywords: cancer; inflammatory mediator; diet; antioxidant; epidemiology; dietary inflammatory index cancer; inflammatory mediator; diet; antioxidant; epidemiology; dietary inflammatory index
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MDPI and ACS Style

Ryu, I.; Kwon, M.; Sohn, C.; Shivappa, N.; Hébert, J.R.; Na, W.; Kim, M.K. The Association between Dietary Inflammatory Index (DII) and Cancer Risk in Korea: A Prospective Cohort Study within the KoGES-HEXA Study. Nutrients 2019, 11, 2560. https://doi.org/10.3390/nu11112560

AMA Style

Ryu I, Kwon M, Sohn C, Shivappa N, Hébert JR, Na W, Kim MK. The Association between Dietary Inflammatory Index (DII) and Cancer Risk in Korea: A Prospective Cohort Study within the KoGES-HEXA Study. Nutrients. 2019; 11(11):2560. https://doi.org/10.3390/nu11112560

Chicago/Turabian Style

Ryu, Injeong; Kwon, Minji; Sohn, Cheongmin; Shivappa, Nitin; Hébert, James R.; Na, Woori; Kim, Mi K. 2019. "The Association between Dietary Inflammatory Index (DII) and Cancer Risk in Korea: A Prospective Cohort Study within the KoGES-HEXA Study" Nutrients 11, no. 11: 2560. https://doi.org/10.3390/nu11112560

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