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Open AccessArticle

Docosahexaenoic Acid Inhibits PTP1B Phosphatase and the Viability of MCF-7 Breast Cancer Cells

1
Department of Medical Chemistry, Medical University of Gdansk, 1 Debinki St., 80-211 Gdansk, Poland
2
Institute of Biomaterials and Biomolecular Systems, Department of Biophysics, University of Stuttgart, 70550 Stuttgart, Germany
3
The Euro-Mediterranean Institute of Science and Technology, 90127 Palermo, Italy
4
Li Ka Shing Applied Virology Institute, Department of Medical Microbiology and Immunology 6-020 Katz Group Centre, University of Alberta, Edmonton, AB T6G 2E1, Canada
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Department of Oncology, University of Alberta, Edmonton, AB T6G 1Z2, Canada
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Department of Physics, CCIS, University of Alberta, Edmonton, AB T6G 2E1, Canada
7
DIMEAS, Politecnico di Torino, Corso Duca degli Abruzzi, 24, 10129 Torino, Italy
*
Author to whom correspondence should be addressed.
Nutrients 2019, 11(11), 2554; https://doi.org/10.3390/nu11112554
Received: 27 September 2019 / Revised: 21 October 2019 / Accepted: 22 October 2019 / Published: 23 October 2019
(This article belongs to the Special Issue Dietary Bioactive Compounds and Human Health and Disease)
Background: Docosahexaenoic acid (DHA) is an essential polyunsaturated fatty acid compound present in deep water fishes and dietary supplements, with a wide spectrum of potential health benefits, ranging from neurological to anti-inflammatory. Methods: Due to the fact that DHA is considered a breast cancer risk reducer, we examined the impact of DHA on MCF-7 breast cancer cells’ viability and its inhibitory properties on protein tyrosine phosphatase 1B (PTP1B), a pro-oncogenic phosphatase. Results: We found that DHA is able to lower both the enzymatic activity of PTP1B phosphatase and the viability of MCF-7 breast cancer cells. We showed that unsaturated DHA possesses a significantly higher inhibitory activity toward PTP1B in comparison to similar fatty acids. We also performed a computational analysis of DHA binding to PTP1B and discovered that it is able to bind to an allosteric binding site. Conclusions: Utilizing both a recombinant enzyme and cellular models, we demonstrated that DHA can be considered a potential pharmacological agent for the prevention of breast cancer. View Full-Text
Keywords: breast cancer; docosahexaenoic acid; omega-3 acids; protein tyrosine phosphatase PTP1B breast cancer; docosahexaenoic acid; omega-3 acids; protein tyrosine phosphatase PTP1B
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MDPI and ACS Style

Kuban-Jankowska, A.; Gorska-Ponikowska, M.; Sahu, K.K.; Kostrzewa, T.; Wozniak, M.; Tuszynski, J. Docosahexaenoic Acid Inhibits PTP1B Phosphatase and the Viability of MCF-7 Breast Cancer Cells. Nutrients 2019, 11, 2554.

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