Next Article in Journal
Characteristics and Glucose Uptake Promoting Effect of Chrysin-Loaded Phytosomes Prepared with Different Phospholipid Matrices
Previous Article in Journal
Effect Modification of Vitamin D Supplementation by Histopathological Characteristics on Survival of Patients with Digestive Tract Cancer: Post Hoc Analysis of the AMATERASU Randomized Clinical Trial
Open AccessArticle

Plasma Kinetics of Choline and Choline Metabolites After A Single Dose of SuperbaBoostTM Krill Oil or Choline Bitartrate in Healthy Volunteers

1
BioTeSys GmbH, Schelztorstraße 54–56, 73728 Esslingen, Germany
2
Department of Mathematics, Natural and Economic Sciences, Ulm University of Applied Sciences, Albert-Einstein-Allee 55, 89081 Ulm, Germany
3
Aker BioMarine Antarctic AS, Oksenøyveien 10, 1327 Lysaker, Norway
*
Author to whom correspondence should be addressed.
Nutrients 2019, 11(10), 2548; https://doi.org/10.3390/nu11102548
Received: 14 August 2019 / Revised: 16 October 2019 / Accepted: 18 October 2019 / Published: 22 October 2019
As an essential nutrient, the organic water-soluble compound choline is important for human health. Choline is required for numerous biological processes, including the synthesis of neurotransmitters, and it is an important prerequisite for structural integrity and the functioning of cells. A choline-rich diet provides crucial choline sources, yet additional choline dietary supplements might be needed to fully meet the body’s requirements. Dependent on the structure of choline in different sources, absorption and metabolism may differ and strongly impact the bioavailability of circulating choline. This study in healthy volunteers aimed to compare the pharmacokinetics of free choline and of selected choline metabolites between the single dose intake of phosphatidylcholine, present in SuperbaBoostTM krill oil, and choline bitartrate salt. Results demonstrate that albeit free choline levels in plasma were comparable between both choline sources, peak choline concentration was reached significantly later upon intake of SuperbaBoostTM. Moreover, the occurrence of choline metabolites differed between the study products. Levels of the biologically important metabolites betaine and dimethylglycine (DMG) were higher, while levels of trimethylamine N-oxide (TMAO) were substantially lower upon intake of SuperbaBoostTM compared to choline bitartrate. View Full-Text
Keywords: choline; pharmacokinetics; Antarctic krill; phosphatidylcholine; SuperbaBoost; choline bitartrate; betaine; dimethylglycine; trimethylamine N-oxide choline; pharmacokinetics; Antarctic krill; phosphatidylcholine; SuperbaBoost; choline bitartrate; betaine; dimethylglycine; trimethylamine N-oxide
Show Figures

Figure 1

MDPI and ACS Style

Mödinger, Y.; Schön, C.; Wilhelm, M.; Hals, P.-A. Plasma Kinetics of Choline and Choline Metabolites After A Single Dose of SuperbaBoostTM Krill Oil or Choline Bitartrate in Healthy Volunteers. Nutrients 2019, 11, 2548.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Search more from Scilit
 
Search
Back to TopTop