Next Article in Journal
Plasma Kinetics of Choline and Choline Metabolites After A Single Dose of SuperbaBoostTM Krill Oil or Choline Bitartrate in Healthy Volunteers
Next Article in Special Issue
Epigenetic Activation of BRCA1 by Genistein In Vivo and Triple Negative Breast Cancer Cells Linked to Antagonism toward Aryl Hydrocarbon Receptor
Previous Article in Journal
The Effect of the Body Mass Indexes of Young Healthy Individuals on the Glyacemic Indexes of Traditional and Modified Vegetarian Meals
Previous Article in Special Issue
Diet, Physical Activity, Obesity, and Breastfeeding: How French People Perceive Factors Associated with Cancer Risk
Open AccessArticle

Effect Modification of Vitamin D Supplementation by Histopathological Characteristics on Survival of Patients with Digestive Tract Cancer: Post Hoc Analysis of the AMATERASU Randomized Clinical Trial

1
Division of Molecular Epidemiology, The Jikei University School of Medicine, 3–25–8, Nishi-Shimbashi, Minato-Ku, Tokyo 105-8461, Japan
2
Celgene K. K., JP TOWER 2–7–2 Marunouchi Chiyoda-ku, Tokyo 100-7010, Japan
3
Department of Pathology, International University of Health and Welfare Hospital, 537–3 Iguchi, Nasushiobara, Tochigi 329-2763, Japan
4
Department of Surgery, International University of Health and Welfare Hospital, 537–3 Iguchi, Nasushiobara, Tochigi 329-2763, Japan
*
Author to whom correspondence should be addressed.
Nutrients 2019, 11(10), 2547; https://doi.org/10.3390/nu11102547
Received: 13 September 2019 / Revised: 18 October 2019 / Accepted: 21 October 2019 / Published: 22 October 2019
(This article belongs to the Special Issue Nutrition and Cancer: From Prevention to Survivorship)
Some coauthors of this study previously performed the AMATERASU randomized, double-blind, placebo-controlled trial of postoperative oral vitamin D supplementation (2,000 IU/day) in 417 patients with stage I to III digestive tract cancer from the esophagus to the rectum who underwent curative surgery (UMIN000001977). We conducted a post-hoc analysis of the AMATERASU trial to explore the effects of modification of vitamin D supplementation by histopathological characteristics on survival. Among patients with poorly differentiated adenocarcinoma, the 5-year relapse-free survival rate of patients supplemented with vitamin D was 91% compared with 63% in the placebo group (hazard ratio [HR], 0.25; 95% confidence interval [CI], 0.08 to 0.78; P = 0.017; P for interaction = 0.023). Similarly, the 5-year overall survival rate was 92% in the vitamin D group compared with 72% in the placebo group (HR, 0.25; 95%CI, 0.07 to 0.94; P = 0.040; P for interaction = 0.012). In contrast, there were no significant effects in other histopathological characteristics between vitamin D and placebo groups. These findings generated the hypothesis that oral vitamin D supplementation may improve both relapse-free survival and overall survival in a subgroup of patients with poorly differentiated adenocarcinoma. View Full-Text
Keywords: prognosis; survival; Vitamin D; supplementation; pathology prognosis; survival; Vitamin D; supplementation; pathology
Show Figures

Figure 1

MDPI and ACS Style

Yonaga, H.; Okada, S.; Akutsu, T.; Ohdaira, H.; Suzuki, Y.; Urashima, M. Effect Modification of Vitamin D Supplementation by Histopathological Characteristics on Survival of Patients with Digestive Tract Cancer: Post Hoc Analysis of the AMATERASU Randomized Clinical Trial. Nutrients 2019, 11, 2547. https://doi.org/10.3390/nu11102547

AMA Style

Yonaga H, Okada S, Akutsu T, Ohdaira H, Suzuki Y, Urashima M. Effect Modification of Vitamin D Supplementation by Histopathological Characteristics on Survival of Patients with Digestive Tract Cancer: Post Hoc Analysis of the AMATERASU Randomized Clinical Trial. Nutrients. 2019; 11(10):2547. https://doi.org/10.3390/nu11102547

Chicago/Turabian Style

Yonaga, Hideyuki; Okada, Shinya; Akutsu, Taisuke; Ohdaira, Hironori; Suzuki, Yutaka; Urashima, Mitsuyoshi. 2019. "Effect Modification of Vitamin D Supplementation by Histopathological Characteristics on Survival of Patients with Digestive Tract Cancer: Post Hoc Analysis of the AMATERASU Randomized Clinical Trial" Nutrients 11, no. 10: 2547. https://doi.org/10.3390/nu11102547

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Search more from Scilit
 
Search
Back to TopTop