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Urine Metabolites and Antioxidant Effect after Oral Intake of Date (Phoenix dactylifera L.) Seeds-Based Products (Powder, Bread and Extract) by Human

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Department of Food, Nutrition and Health, College of Food and Agriculture, United Arab Emirates University, Al Ain PO Box 15551, UAE
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Quality, Safety and Bioactivity of Plant Foods, CEBAS-CSIC, PO Box 164, Espinardo, 30100 Murcia, Spain
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Department of Pediatrics, College of Medicine and Health Sciences, United Arab Emirates University, Al Ain P.O. Box 15551, UAE
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Author to whom correspondence should be addressed.
Nutrients 2019, 11(10), 2489; https://doi.org/10.3390/nu11102489
Received: 14 August 2019 / Revised: 3 October 2019 / Accepted: 7 October 2019 / Published: 16 October 2019
A cross-over study was conducted in 16 healthy adult volunteers to describe the urinary excretion of polyphenols from date seeds and investigate the antioxidant effect after consumption of different doses of date seeds powder (DSP), bread (DSB) and extract (DSE). After 12 h of fasting, one of the six treatments (0.25 g and 0.5 g/kg bodyweight DSP, 360 g of 10% and 15% DSB, 30 mg and 60 mg/kg bodyweight DSE) was provided along with breakfast, with a two weeks wash-out period between 2 consecutive treatments. Blood was drawn at baseline, 1, 2, 8 and 24 h post intake. Urine was collected at baseline, 3, 8, and 24 h post intake. An abundant release of polyphenols was detected in urine within the 0–3 h post intake, reached a peak at 8 h, then decreased with polyphenols still being detected up to 24 h post intake. The antioxidant defence system, as measured by reduced glutathione (GSH), was strengthened as soon as 1 h and up to 8 h post intake. Markers of protein and lipid oxidative damages were reduced from 1 h and up to 8 and 24 h post intake, respectively. This supports an antioxidant effect of date seeds products in humans, most probably due to their polyphenols. View Full-Text
Keywords: date seeds; oxidative damages; antioxidant; human; urine metabolites; polyphenols; proanthocyanidins; UPLC-ESI-QTOF(MS/MS) date seeds; oxidative damages; antioxidant; human; urine metabolites; polyphenols; proanthocyanidins; UPLC-ESI-QTOF(MS/MS)
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Platat, C.; Hilary, S.; Tomas-Barberan, F.A.; Martinez-Blazquez, J.A.; Al-Meqbali, F.; Souka, U.; Al-Hammadi, S.; Ibrahim, W. Urine Metabolites and Antioxidant Effect after Oral Intake of Date (Phoenix dactylifera L.) Seeds-Based Products (Powder, Bread and Extract) by Human. Nutrients 2019, 11, 2489.

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