The Impact of Obesity on the Association between Vitamin D Deficiency and Cardiovascular Disease
Abstract
:1. Introduction
2. Links between Vitamin D Status and Cardiovascular Disease
2.1. Early Evidence from Association Studies and Experimental Data
2.2. Prospective Studies and Randomized Clinical Trials
3. The Inter-Relationship between Obesity, Vitamin D, and Cardiovascular Health
3.1. Effects of Obesity on Vitamin D Deficiency and Cardiovascular Disease
3.2. Pathophysiology of Vitamin D Deficiency in Obesity
3.3. Effects of Vitamin D Deficiency on Cardiovascular Health in Obese and Non-Obese Populations
4. Future Perspectives
Author Contributions
Funding
Conflicts of Interest
References
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First Author, Year | Study Type | Population | Vitamin D Parameter | Outcome | Reported Interaction with Vitamin D |
---|---|---|---|---|---|
Studies in animals | |||||
Salum, 2013 [31] | Experimental | Diabetic rats | Vitamin D supplementation | Carboxymethylycin accumulation | Negative, significant |
Ellam, 2014 [28] | Experimental | Apolipoprotein E knockout mice | Induced deficiency | Atheroma calcification | Positive, significant |
Yin, 2015 [24] | Experimental | Hypercholesterolemic swine | Induced deficiency | Macrophage recruitment | Positive, significant |
Chen, 2016 [25] | Experimental | Hypercholesterolemic swine | Induced deficiency | NFkB activity | Positive, significant |
Chang, 2017 [72] | Experimental | Obese rats | Induced deficiency | Macrophage recruitment | Positive, significant |
Farhangi, 2017 [30] | Experimental | Obese rats | Induced deficiency | Superoxide dismutase/Catalase activity | Negative, significant |
Hadjadj, 2019 [27] | Experimental | Hyperandrogenic female rats | Induced deficiency | LAD relaxation capacity | Negative, significant |
Studies in humans | |||||
Hsia, 2007 [34] | Experimental, clinical | Postmenopausal women | Vitamin D supplementation | Major adverse cardiovascular events / Stroke | Non-significant |
Giovanucci, 2008 [19] | Observational clinical | Healthy adult men | Baseline concentrations | Major adverse cardiovascular events | Inverse, significant |
Cauley, 2013 [35] | Post-hoc experimental, clinical | Postmenopausal women | Vitamin D supplementation | All-cause mortality | Non-significant |
Martins, 2014 [76] | Experimental, clinical | Obese Adults | Vitamin D supplementation | Arterial stiffness | Inverse, significant |
Schöttker, 2014 [22] | Meta-analysis | General population | Baseline concentrations | Cardiovascular mortality | Inverse, significant |
Welles, 2014 [20] | Observational clinical | Stable cardiovascular disease | Baseline concentrations | Major adverse cardiovascular events | Inverse, significant |
Sunbul, 2015 [29] | Observational | Healthy adults | Baseline concentrations | Global longitudinal strain | Statistically significant |
Faridi, 2017 [23] | Observational clinical | General population | Baseline concentrations | Total cholesterol | Inverse, significant |
Scragg, 2017 [36] | Experimental, clinical | General population | Vitamin D supplementation | Cardiovascular disease incidence | Non-significant |
Zhang, 2017 [21] | Meta-analysis | General population | Baseline concentrations | Cardiovascular mortality | Inverse, significant |
Manson, 2019 [37] | Experimental, clinical | General population | Vitamin D supplementation | Major adverse cardiovascular events / Stroke | Non-significant |
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Paschou, S.A.; Kosmopoulos, M.; Nikas, I.P.; Spartalis, M.; Kassi, E.; Goulis, D.G.; Lambrinoudaki, I.; Siasos, G. The Impact of Obesity on the Association between Vitamin D Deficiency and Cardiovascular Disease. Nutrients 2019, 11, 2458. https://doi.org/10.3390/nu11102458
Paschou SA, Kosmopoulos M, Nikas IP, Spartalis M, Kassi E, Goulis DG, Lambrinoudaki I, Siasos G. The Impact of Obesity on the Association between Vitamin D Deficiency and Cardiovascular Disease. Nutrients. 2019; 11(10):2458. https://doi.org/10.3390/nu11102458
Chicago/Turabian StylePaschou, Stavroula A., Marinos Kosmopoulos, Ilias P. Nikas, Michael Spartalis, Evanthia Kassi, Dimitrios G. Goulis, Irene Lambrinoudaki, and Gerasimos Siasos. 2019. "The Impact of Obesity on the Association between Vitamin D Deficiency and Cardiovascular Disease" Nutrients 11, no. 10: 2458. https://doi.org/10.3390/nu11102458
APA StylePaschou, S. A., Kosmopoulos, M., Nikas, I. P., Spartalis, M., Kassi, E., Goulis, D. G., Lambrinoudaki, I., & Siasos, G. (2019). The Impact of Obesity on the Association between Vitamin D Deficiency and Cardiovascular Disease. Nutrients, 11(10), 2458. https://doi.org/10.3390/nu11102458