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Open AccessArticle

Cortical Visual Evoked Potentials and Growth in Infants Fed with Bioactive Compounds-Enriched Infant Formula: Results from COGNIS Randomized Clinical Trial

1
EURISTIKOS Excellence Centre for Paediatric Research, Biomedical Research Centre, University of Granada, 18016 Granada, Spain
2
Department of Paediatrics, School of Medicine, University of Granada, Avda. Investigación 11, 18016 Granada, Spain
3
Mind, Brain and Behaviour Research Centre-CIMCYC, University of Granada, 18011 Granada, Spain
4
Nutrition and Biochemistry Department, Faculty of Sciences, Pontificia Universidad Javeriana, Bogotá 110231, Colombia
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Clinical Service of Neurophysiology, Clinical University Hospital San Cecilio, 18016 Granada, Spain
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Department of Biostatistics, School of Medicine, University of Granada, 18016 Granada, Spain
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Ordesa Laboratories, S.L., 08820 Barcelona, Spain
8
Spanish Network of Biomedical Research in Epidemiology and Public Health (CIBERESP), Granada’s node, Institute of Health Carlos III, 28029 Madrid, Spain
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Nutrients 2019, 11(10), 2456; https://doi.org/10.3390/nu11102456
Received: 23 September 2019 / Revised: 9 October 2019 / Accepted: 12 October 2019 / Published: 14 October 2019
Postnatal nutrition is essential for growth and neurodevelopment. We analyzed the influence of a new enriched-infant formula with bioactive compounds on growth, neurodevelopment, and visual function (VF) in healthy infants during their first 18 months of life. A total of 170 infants were randomized in the COGNIS randomized clinical trial (RCT) to receive a standard infant formula (SF = 85) or a new experimental infant formula supplemented with functional nutrients (EF = 85). As a control, 50 breastfed infants (BF) were enrolled. Growth patterns were evaluated up to 18 months of life; neurodevelopment was assessed by general movements at 2, 3, and 4 months; VF was measured by cortical visual evoked potentials at 3 and 12 months. No differences in growth and neurodevelopment were found between groups. Regarding VF, SF and EF infants presented prolonged latencies and lower amplitudes in the P100 wave than BF infants. In the EF group, a higher percentage of infants presented response at 7½′ of arc at 12 months compared to 3 months of age; a similar proportion of BF and EF infants presented responses at 7½′ of arc at 12 months of age. Early nutritional intervention with bioactive compounds could narrow the gap in growth and neurodevelopment between breastfed and formula-fed infants. View Full-Text
Keywords: breastfeeding; infant formula; bioactive compounds; visual evoked potentials; growth breastfeeding; infant formula; bioactive compounds; visual evoked potentials; growth
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Nieto-Ruiz, A.; García-Santos, J.A.; Bermúdez, M.G.; Herrmann, F.; Diéguez, E.; Sepúlveda-Valbuena, N.; García, S.; Miranda, M.T.; De-Castellar, R.; Rodríguez-Palmero, M.; Catena, A.; Campoy, C. Cortical Visual Evoked Potentials and Growth in Infants Fed with Bioactive Compounds-Enriched Infant Formula: Results from COGNIS Randomized Clinical Trial. Nutrients 2019, 11, 2456.

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