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Dietary Protein, Exercise, and Frailty Domains

Faculty of Sports and Nutrition, Center of Expertise Urban Vitality, Amsterdam University of Applied Sciences, 1097 DZ Amsterdam, The Netherlands
Faculty Health, Center of Expertise Urban Vitality, Amsterdam University of Applied Sciences, 1097 DZ Amsterdam, The Netherlands
Amsterdam University Medical Centers, University of Amsterdam, 1012 WX Amsterdam, The Netherlands
Author to whom correspondence should be addressed.
Nutrients 2019, 11(10), 2399;
Received: 28 July 2019 / Revised: 5 September 2019 / Accepted: 6 September 2019 / Published: 8 October 2019
(This article belongs to the Special Issue Frailty: Role of Nutrition and Exercise)
Increasing awareness of the impact of frailty on elderly people resulted in research focusing on factors that contribute to the development and persistence of frailty including nutrition and physical activity. Most effort so far has been spent on understanding the association between protein intake and the physical domain of frailty. Far less is known for other domains of frailty: cognition, mood, social health and comorbidity. Therefore, in the present narrative review, we elaborate on the evidence currently known on the association between protein and exercise as well as the broader concept of frailty. Most, but not all, identified studies concluded that low protein intake is associated with a higher prevalence and incidence of physical frailty. Far less is known on the broader concept of frailty. The few studies that do look into this association find a clear beneficial effect of physical activity but no conclusions regarding protein intake can be made yet. Similar, for other important aspects of frailty including mood, cognition, and comorbidity, the number of studies are limited and results are inconclusive. Future studies need to focus on the relation between dietary protein and the broader concept of frailty and should also consider the protein source, amount and timing. View Full-Text
Keywords: frailty; protein; physical activity frailty; protein; physical activity
MDPI and ACS Style

Schoufour, J.D.; Overdevest, E.; Weijs, P.J.M.; Tieland, M. Dietary Protein, Exercise, and Frailty Domains. Nutrients 2019, 11, 2399.

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