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Allium hookeri Root Extract Inhibits Adipogenesis by Promoting Lipolysis in High Fat Diet-Induced Obese Mice

1
Research and Development Division, World Institute of Kimchi, Nam-Gu, Gwangju 61755, Korea
2
Functional Food & Nutrition Division, Department of Agro-food resources, Rural Development Administration, Wanju, Jeonbuk 55365, Korea
*
Authors to whom correspondence should be addressed.
Nutrients 2019, 11(10), 2262; https://doi.org/10.3390/nu11102262
Received: 16 August 2019 / Revised: 15 September 2019 / Accepted: 17 September 2019 / Published: 20 September 2019
Allium hookeri (AH) is widely consumed as a herbal medicine. It possesses biological activity against metabolic diseases. The objective of this study was to investigate effects of AH root water extract (AHR) on adipogenesis in 3T3-L1 cells and in high-fat diet (HFD)-induced obese mice. AHR inhibited lipid accumulation during adipocyte differentiation by downregulation of gene expression, such as hormone sensitive lipase (HSL), lipoprotein lipase (LPL) and an adipogenic gene, CCAAT/enhancer binding protein-α in 3T3-L1 preadipocytes. Oral administration of AHR significantly suppressed body weight gain, adipose tissue weight, serum leptin levels, and adipocyte cell size in HFD-induced obese mice. Moreover, AHR significantly decreased hepatic mRNA expression levels of cholesterol synthesis genes, such as 3-hydroxy-3-methylglutaryl CoA reductase, sterol regulatory element-binding transcription factor (SREBP)-2, and low-density lipoprotein receptor, as well as fatty acid synthesis genes, such as SREBP-1c and fatty acid synthase. Serum triglyceride levels were also lowered by AHR, likely as a result of the upregulating gene involved in fatty acid β-oxidation, carnitine palmitoyltransferase 1a, in the liver. AHR treatment activated gene expression of peroxisome proliferator-activated receptor-γ, which might have promoted HSL and LPL-medicated lipolysis, thereby reducing white adipose tissue weight. In conclusion, AHR treatment can improve metabolic alterations induced by HFD in mice by modifying expression levels of genes involved in adipogenesis, lipogenesis, and lipolysis in the white adipose tissue and liver. View Full-Text
Keywords: Allium hookeri root; anti-obesity; adipogenesis; lipolysis; high fat diet Allium hookeri root; anti-obesity; adipogenesis; lipolysis; high fat diet
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Kim, H.J.; Lee, M.-J.; Jang, J.-Y.; Lee, S.-H. Allium hookeri Root Extract Inhibits Adipogenesis by Promoting Lipolysis in High Fat Diet-Induced Obese Mice. Nutrients 2019, 11, 2262.

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