Next Article in Journal
Dietary Zinc and Risk of Prostate Cancer in Spain: MCC-Spain Study
Previous Article in Journal
Association of l-Arginine Supplementation with Markers of Endothelial Function in Patients with Cardiovascular or Metabolic Disorders: A Systematic Review and Meta-Analysis
Article Menu
Issue 1 (January) cover image

Export Article

Open AccessArticle
Nutrients 2019, 11(1), 17; https://doi.org/10.3390/nu11010017

Inula japonica Thunb. Flower Ethanol Extract Improves Obesity and Exercise Endurance in Mice Fed a High-Fat Diet

1
Department of Food Biotechnology, Korea University of Science and Technology, Wanju-gun, Jeollabuk-do 55365, Korea
2
Research Division of Food Functionality, Korea Food Research Institute, Wanju-gun, Jeollabuk-do 55365, Korea
*
Author to whom correspondence should be addressed.
Received: 30 November 2018 / Revised: 17 December 2018 / Accepted: 19 December 2018 / Published: 20 December 2018
Full-Text   |   PDF [2372 KB, uploaded 24 December 2018]   |  

Abstract

Inula japonica Thunb. (Asteraceae) is a flowering plant that grows mainly in Korea, Japan, and China and its flower extract has diverse biological effects such as anti-inflammatory and antioxidative activities. However, the effects on obesity and enhancement of endurance capacity have not been explored yet. This study aims to reveal the effects of I. japonica flower ethanol extract (IJE) on obesity and endurance capacity in high-fat diet (HFD) fed C57BL/6J mice and the mechanism. IJE inhibited lipid accumulation in 3T3-L1 adipocytes in vitro. Also, IJE-fed mice showed reduced body weight gain, hepatic lipid, and body fat mass, and increased muscle weight. IJE reduced lipid accumulation in the liver and adipose tissue by decreasing lipogenic and adipogenic gene expression. Additionally, consumption of low-dose IJE significantly enhanced endurance capacity via increasing AMP-activated protein kinase activity and mRNA levels of Myh7 and Myh2. Luteolin and 1β-hydroxyalantolactone (1β-HA), compounds of IJE, are involved in anti-adipogenesis in the 3T3-L cells and only luteolin increased the protein levels of MHC during C2C12 myoblast differentiation. Collectively, our results suggest that consumption of IJE not only helps to prevent obesity but also enhances endurance capacity reduced by HFD. View Full-Text
Keywords: Inula japonica; obesity; exercise endurance; adipogenesis; lipogenesis; myogenesis Inula japonica; obesity; exercise endurance; adipogenesis; lipogenesis; myogenesis
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
SciFeed

Share & Cite This Article

MDPI and ACS Style

Park, S.-H.; Lee, D.-H.; Kim, M.J.; Ahn, J.; Jang, Y.-J.; Ha, T.-Y.; Jung, C.H. Inula japonica Thunb. Flower Ethanol Extract Improves Obesity and Exercise Endurance in Mice Fed a High-Fat Diet. Nutrients 2019, 11, 17.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Nutrients EISSN 2072-6643 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top