Next Article in Journal
Whole Body Protein Oxidation Unaffected after a Protein Restricted Diet in Healthy Young Males
Previous Article in Journal
Bamboo Stems (Phyllostachys nigra variety henosis) Containing Polyphenol Mixtures Activate Nrf2 and Attenuate Phenylhydrazine-Induced Oxidative Stress and Liver Injury
Article Menu
Issue 1 (January) cover image

Export Article

Open AccessFeature PaperArticle
Nutrients 2019, 11(1), 113; https://doi.org/10.3390/nu11010113

Avocado Oil Extract Modulates Auditory Hair Cell Function through the Regulation of Amino Acid Biosynthesis Genes

1
Department of Oriental Medicine Biotechnology, College of Life Sciences and Graduate School of Biotechnology, Kyung Hee University, Global Campus, Gyeonggi 17104, Korea
2
Gachon Institute of Pharmaceutical Sciences, College of Pharmacy, Gachon University, Incheon 21936, Korea
3
R&D Center, Dongkook Pharm. Co., Ltd., Gyeonggi 16229, Korea
4
College of Pharmacy, Yonsei Institute of Pharmaceutical Sciences, Yonsei University, Incheon 21983, Korea
5
Department of Otorhinolaryngology, Yonsei University College of Medicine, Seoul 03722, Korea
6
Department of Preventive Pharmacy and Toxicology, College of Pharmacy, Kyung Hee University, Seoul 02453, Korea
*
Authors to whom correspondence should be addressed.
These two authors contributed equally to this work.
Received: 5 December 2018 / Revised: 24 December 2018 / Accepted: 5 January 2019 / Published: 8 January 2019
  |  
PDF [2478 KB, uploaded 8 January 2019]
  |     |  

Abstract

Sensorineural hearing loss (SNHL) is one of the most common causes of disability, affecting over 466 million people worldwide. However, prevention or therapy of SNHL has not been widely studied. Avocado oil has shown many health benefits but it has not yet been studied in regards to SNHL. Therefore, we aimed to investigate the efficacy of avocado oil on SNHL in vitro and in vivo and elucidate its mode of action. For the present study, we used enhanced functional avocado oil extract (DKB122). DKB122 led to recovery of otic hair cells in zebrafish after neomycin-induced otic cell damage. Also, DKB122 improved auditory sensory transmission function in a mouse model of noise induced-hearing loss and protected sensory hair cells in the cochlea. In addition, RNA sequencing was performed to elucidate the mechanism involved. KEGG pathway enrichment analysis of differentially expressed genes showed that DKB122 protected House Ear Institute-Organ of Corti 1 (HEI-OC1) cells against neomycin-related alterations in gene expression due to oxidative stress, cytokine production and protein synthesis. View Full-Text
Keywords: avocado oil; sensorineural hearing loss; hair cell; zebrafish; mice; HEI-OC1 avocado oil; sensorineural hearing loss; hair cell; zebrafish; mice; HEI-OC1
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
SciFeed

Share & Cite This Article

MDPI and ACS Style

Nam, Y.H.; Rodriguez, I.; Jeong, S.Y.; Pham, T.N.M.; Nuankaew, W.; Kim, Y.H.; Castañeda, R.; Jeong, S.Y.; Park, M.S.; Lee, K.W.; Lee, J.S.; Kim, D.H.; Park, Y.H.; Kim, S.H.; Moon, I.S.; Choung, S.-Y.; Hong, B.N.; Jeong, K.W.; Kang, T.H. Avocado Oil Extract Modulates Auditory Hair Cell Function through the Regulation of Amino Acid Biosynthesis Genes. Nutrients 2019, 11, 113.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Nutrients EISSN 2072-6643 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top