Next Article in Journal
Lactobacillus acidophilus DDS-1 Modulates the Gut Microbiota and Improves Metabolic Profiles in Aging Mice
Next Article in Special Issue
High Fat/High Glucose Diet Induces Metabolic Syndrome in an Experimental Rat Model
Previous Article in Journal
Prospective Associations of Erythrocyte Composition and Dietary Intake of n-3 and n-6 PUFA with Measures of Cognitive Function
Previous Article in Special Issue
French Recommendations for Sugar Intake in Adults: A Novel Approach Chosen by ANSES
Open AccessArticle

Changes in Plasma Acylcarnitine and Lysophosphatidylcholine Levels Following a High-Fructose Diet: A Targeted Metabolomics Study in Healthy Women

Institute of Clinical Nutrition, University of Hohenheim, Fruwirthstr 12, 70599 Stuttgart, Germany
*
Author to whom correspondence should be addressed.
Nutrients 2018, 10(9), 1254; https://doi.org/10.3390/nu10091254
Received: 23 July 2018 / Revised: 20 August 2018 / Accepted: 30 August 2018 / Published: 6 September 2018
(This article belongs to the Special Issue Fructose and Glucose for Human Health)
Background: The consumption of high amounts of fructose is associated with metabolic diseases. However, the underlying mechanisms are largely unknown. Objective: To determine the effects of high fructose intake on plasma metabolomics. Study design: We enrolled 12 healthy volunteers (six lean and six obese women, age 24–35 years) in a crossover intervention study. All participants carried out three diets: (1) low fructose (<10 g/day); (2) high fructose (100 g/day) from natural food sources (fruit); and (3) high fructose (100 g/day) from high fructose syrup (HFS). Outcome measures: The primary outcome was changes in plasma metabolites measured by targeted metabolomics. Results: High compared to low fructose diets caused a marked metabolite class separation, especially because of changes in acylcarnitine and lysophosphatidylcholine levels. Both high fructose diets resulted in a decrease in mean acylcarnitine levels in all subjects, and an increase in mean lysophosphatidylcholine and diacyl-phosphatidylcholine levels in obese individuals. Medium chain acylcarnitines were negatively correlated with serum levels of liver enzymes and with the fatty liver index. Discussion: The metabolic shifts induced by high fructose consumption suggest an inhibition of mitochondrial β-oxidation and an increase in lipid peroxidation. The effects tended to be more pronounced following the HFS than the fruit diet. View Full-Text
Keywords: fructose; targeted metabolomics; metabolic syndrome; liver disease fructose; targeted metabolomics; metabolic syndrome; liver disease
Show Figures

Figure 1

MDPI and ACS Style

Gonzalez-Granda, A.; Damms-Machado, A.; Basrai, M.; Bischoff, S.C. Changes in Plasma Acylcarnitine and Lysophosphatidylcholine Levels Following a High-Fructose Diet: A Targeted Metabolomics Study in Healthy Women. Nutrients 2018, 10, 1254.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop