Next Article in Journal
Effect of Whey Protein Supplementation on Physical Performance and Body Composition in Army Initial Entry Training Soldiers
Next Article in Special Issue
A Comparison of Psychophysical Dose-Response Behaviour across 16 Sweeteners
Previous Article in Journal
Dietary Interventions for the Prevention of Type 2 Diabetes in High-Risk Groups: Current State of Evidence and Future Research Needs
Previous Article in Special Issue
Exploring Drivers of Liking of Low-Phenylalanine Products in Subjects with Phenyilketonuria Using Check-All-That-Apply Method
Article Menu
Issue 9 (September) cover image

Export Article

Open AccessArticle
Nutrients 2018, 10(9), 1246;

Fatty Acid Lingual Application Activates Gustatory and Reward Brain Circuits in the Mouse

Neurosciences Intégratives et Cliniques EA481, Université de Bourgogne Franche-Comté (UBFC), 25000 Besançon, France
Unité Inserm U1234, Université de Rouen/IRIB, Faculté de Médecine et Pharmacie, 76183 Rouen CEDEX, France
Physiologie de la Nutrition & Toxicologie (NUTox), Agro-Sup, UMR U1231 INSERM/Université de Bourgogne Franche-Comté (UBFC), 6, Boulevard Gabriel, 21000 Dijon, France
Author to whom correspondence should be addressed.
Received: 12 August 2018 / Revised: 27 August 2018 / Accepted: 4 September 2018 / Published: 6 September 2018
(This article belongs to the Special Issue Taste, Nutrition and Health)
Full-Text   |   PDF [1317 KB, uploaded 6 September 2018]   |  


The origin of spontaneous preference for dietary lipids in humans and rodents is debated, though recent compelling evidence has shown the existence of fat taste that might be considered a sixth taste quality. We investigated the implication of gustatory and reward brain circuits, triggered by linoleic acid (LA), a long-chain fatty acid. The LA was applied onto the circumvallate papillae for 30 min in conscious C57BL/6J mice, and neuronal activation was assessed using c-Fos immunohistochemistry. By using real-time reverse transcription polymerase chain reaction (RT-qPCR), we also studied the expression of mRNA encoding brain-derived neurotrophic factor (BDNF), Zif-268, and Glut-1 in some brain areas of these animals. LA induced a significant increase in c-Fos expression in the nucleus of solitary tract (NST), parabrachial nucleus (PBN), and ventroposterior medialis parvocellularis (VPMPC) of the thalamus, which are the regions known to be activated by gustatory signals. LA also triggered c-Fos expression in the central amygdala and ventral tegmental area (VTA), involved in food reward, in conjunction with emotional traits. Interestingly, we noticed a high expression of BDNF, Zif-268, and Glut-1 mRNA in the arcuate nucleus (Arc) and hippocampus (Hipp), where neuronal activation leads to memory formation. Our study demonstrates that oral lipid taste perception might trigger the activation of canonical gustatory and reward pathways. View Full-Text
Keywords: linoleic acid; gustation; hedonic; BDNF; fat taste; c-Fos; Zif-268; Glut-1 linoleic acid; gustation; hedonic; BDNF; fat taste; c-Fos; Zif-268; Glut-1

Graphical abstract

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

Share & Cite This Article

MDPI and ACS Style

Peterschmitt, Y.; Abdoul-Azize, S.; Murtaza, B.; Barbier, M.; Khan, A.S.; Millot, J.-L.; Khan, N.A. Fatty Acid Lingual Application Activates Gustatory and Reward Brain Circuits in the Mouse. Nutrients 2018, 10, 1246.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Nutrients EISSN 2072-6643 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top