Next Article in Journal
Dietary Patterns and Poor Semen Quality Risk in Men: A Cross-Sectional Study
Next Article in Special Issue
Efficacy of an Oral Rehydration Solution Enriched with Lactobacillus reuteri DSM 17938 and Zinc in the Management of Acute Diarrhoea in Infants: A Randomized, Double-Blind, Placebo-Controlled Trial
Previous Article in Journal
Resveratrol Counteracts Insulin Resistance—Potential Role of the Circulation
Previous Article in Special Issue
Bacillus clausii for the Treatment of Acute Diarrhea in Children: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Human Milk Oligosaccharides: 2′-Fucosyllactose (2′-FL) and Lacto-N-Neotetraose (LNnT) in Infant Formula

KidZ Health Castle, UZ Brussel, Vrije Universiteit Brussel, 1090 Brussels, Belgium
Department of Gastro-Intestinal Health, Nestlé Institute of Health Sciences, Nestlé Research, Nestec Ltd., 1015 Lausanne, Switzerland
Neonatal Pediatrics, Polytechnic University of Marche, 60121 Ancona, Italy
Department of Paediatrics, Nutrition and Metabolic Diseases, The Children’s Memorial Health Institute, 04-730 Warsaw, Poland
Department of Public Health, University of Turku and Turku University Hospital, 20014 Turku, Finland
Neonatology Division, Research Institute University Hospital Gregorio Marañón, Complutense University, 28009 Madrid, Spain
Department of Pediatrics, Samara State Medical University, 443084 Samara, Russia
Citadelle For Life, 1000 Brussels, Belgium
Neonatology, Croix-Rousse Hospital, Lyon and CarMen Unit, INSERM U1060, INRA U197, Claude Bernard University, 69100 Lyon 1, France
Nestlé Nutrition Institute, 60528 Frankfurt/Main, Germany
Paediatric Nutrition, UCL Great Ormond Street Institute of Child Health, London WC1N 1EH, UK
Department of Paediatrics and Adolescent Medicine, Division of Paediatric Endocrinology and Diabetes, Centre for Hormonal Disorders in Children and Adolescents, Ulm University Hospital, 89075 Ulm, Germany
Author to whom correspondence should be addressed.
Nutrients 2018, 10(9), 1161;
Received: 23 July 2018 / Revised: 9 August 2018 / Accepted: 14 August 2018 / Published: 24 August 2018
(This article belongs to the Special Issue Probiotics and Prebiotics in Pediatrics)
The authors reviewed the published evidence on the presence of oligosaccharides in human milk (HMO) and their benefits in in vitro and in vivo studies. The still limited data of trials evaluating the effect of mainly 2′-fucosyllactose (2′-FL) on the addition of some of HMOs to infant formula were also reviewed. PubMed was searched from January 1990 to April 2018. The amount of HMOs in mother’s milk is a dynamic process as it changes over time. Many factors, such as duration of lactation, environmental, and genetic factors, influence the amount of HMOs. HMOs may support immune function development and provide protection against infectious diseases directly through the interaction of the gut epithelial cells or indirectly through the modulation of the gut microbiota, including the stimulation of the bifidobacteria. The limited clinical data suggest that the addition of HMOs to infant formula seems to be safe and well tolerated, inducing a normal growth and suggesting a trend towards health benefits. HMOs are one of the major differences between cow’s milk and human milk, and available evidence indicates that these components do have a health promoting benefit. The addition of one or two of these components to infant formula is safe, and brings infant formula closer to human milk. More prospective, randomized trials in infants are need to evaluate the clinical benefit of supplementing infant formula with HMOs. View Full-Text
Keywords: breast feeding; formula feeding; human milk oligosaccharide; 2′-fucosyllactose; Lacto-N-neotetraose; microbiota; bifidobacteria breast feeding; formula feeding; human milk oligosaccharide; 2′-fucosyllactose; Lacto-N-neotetraose; microbiota; bifidobacteria
MDPI and ACS Style

Vandenplas, Y.; Berger, B.; Carnielli, V.P.; Ksiazyk, J.; Lagström, H.; Sanchez Luna, M.; Migacheva, N.; Mosselmans, J.-M.; Picaud, J.-C.; Possner, M.; Singhal, A.; Wabitsch, M. Human Milk Oligosaccharides: 2′-Fucosyllactose (2′-FL) and Lacto-N-Neotetraose (LNnT) in Infant Formula. Nutrients 2018, 10, 1161.

AMA Style

Vandenplas Y, Berger B, Carnielli VP, Ksiazyk J, Lagström H, Sanchez Luna M, Migacheva N, Mosselmans J-M, Picaud J-C, Possner M, Singhal A, Wabitsch M. Human Milk Oligosaccharides: 2′-Fucosyllactose (2′-FL) and Lacto-N-Neotetraose (LNnT) in Infant Formula. Nutrients. 2018; 10(9):1161.

Chicago/Turabian Style

Vandenplas, Yvan, Bernard Berger, Virgilio P. Carnielli, Janusz Ksiazyk, Hanna Lagström, Manuel Sanchez Luna, Natalia Migacheva, Jean-Marc Mosselmans, Jean-Charles Picaud, Mike Possner, Atul Singhal, and Martin Wabitsch. 2018. "Human Milk Oligosaccharides: 2′-Fucosyllactose (2′-FL) and Lacto-N-Neotetraose (LNnT) in Infant Formula" Nutrients 10, no. 9: 1161.

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

Back to TopTop