There Is No Association between Coeliac Disease and Autoimmune Pancreatitis
by
Giulia De Marchi 1, Giovanna Zanoni 2, Maria Cristina Conti Bellocchi 1, Elena Betti 3, Monica Brentegani 2, Paola Capelli 4, Valeria Zuliani 1, Luca Frulloni 1, Catherine Klersy 5 and Rachele Ciccocioppo 1,*
Giulia De Marchi 1, Giovanna Zanoni 2, Maria Cristina Conti Bellocchi 1, Elena Betti 3, Monica Brentegani 2, Paola Capelli 4, Valeria Zuliani 1, Luca Frulloni 1, Catherine Klersy 5 and Rachele Ciccocioppo 1,*
1
Gastroenterology Unit, Department of Medicine, AOUI Policlinico G.B. Rossi, University of Verona; Piazzale L.A. Scuro, 10, 37134 Verona, Italy
2
Immunology Unit, Department of Pathology and Diagnostics, AOUI Policlinico G.B. Rossi, Piazzale L.A. Scuro, 10, 37134 Verona, Italy
3
Clinica Medica I, Department of Internal Medicine, IRCCS Policlinico San Matteo Foundation, Piazzale Golgi, 19, 27100 Pavia, Italy
4
Pathology Unit, Department of Pathology and Diagnostics, AOUI Policlinico G.B. Rossi, Piazzale L.A. Scuro, 10, 37134 Verona, Italy
5
Clinical Epidemiology & Biometry Unit, IRCCS Fondazione Policlinico San Matteo; Viale Golgi 19, 27100 Pavia, Italy
*
Author to whom correspondence should be addressed.
Nutrients 2018, 10(9), 1157; https://doi.org/10.3390/nu10091157
Received: 1 August 2018 / Revised: 20 August 2018 / Accepted: 22 August 2018 / Published: 24 August 2018
(This article belongs to the Special Issue Extraintestinal Manifestations of Coeliac Disease)
Autoimmune pancreatitis (AIP) is a rare disorder whose association with coeliac disease (CD) has never been investigated, although CD patients display a high prevalence of both endocrine and exocrine pancreatic affections. Therefore, we sought to evaluate the frequency of CD in patients with AIP and in further medical pancreatic disorders. The screening for CD was carried out through the detection of tissue transglutaminase (tTG) autoantibodies in sera of patients retrospectively enrolled and divided in four groups: AIP, chronic pancreatitis, chronic asymptomatic pancreatic hyperenzymemia (CAPH), and control subjects with functional dyspepsia. The search for anti-endomysium autoantibodies was performed in those cases with borderline or positive anti-tTG values. Duodenal biopsy was offered to all cases showing positive results. One patient out of 72 (1.4%) with AIP had already been diagnosed with CD and was following a gluten-free diet, while one case out of 71 (1.4%) with chronic pancreatitis and one out of 92 (1.1%) control subjects were diagnosed with de novo CD. No cases of CD were detected in the CAPH group. By contrast, a high prevalence of cases with ulcerative colitis was found in the AIP group (13.8%). Despite a mutual association between CD and several autoimmune disorders, our data do not support the serologic screening for CD in AIP. Further studies will clarify the usefulness of CD serologic screening in other pancreatic disorders.
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MDPI and ACS Style
De Marchi, G.; Zanoni, G.; Conti Bellocchi, M.C.; Betti, E.; Brentegani, M.; Capelli, P.; Zuliani, V.; Frulloni, L.; Klersy, C.; Ciccocioppo, R. There Is No Association between Coeliac Disease and Autoimmune Pancreatitis. Nutrients 2018, 10, 1157.
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