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The Effect of Diet on Improved Endurance in Male C57BL/6 Mice

Department of Pharmaceutical Sciences, College of Pharmacy, University of South Florida, Tampa, FL 33612, USA
NutriFusion®, LLC, Naples, FL 34109, USA
James A. Haley VA Medical Center, Tampa, FL 33612, USA
Shriners Hospital for Children, Tampa, FL 33612, USA
Author to whom correspondence should be addressed.
Nutrients 2018, 10(8), 1101;
Received: 10 July 2018 / Revised: 13 August 2018 / Accepted: 14 August 2018 / Published: 16 August 2018
The consumption of fruits and vegetables appears to help with maintaining an adequate level of exercise and improves endurance. However, the mechanisms that are involved in this process are not well understood. In the current study, the impact of diets enriched in fruits and vegetables (GrandFusion®) on exercise endurance was examined in a mouse model. GrandFusion (GF) diets increased mitochondrial DNA and enzyme activity, while they also stimulated mitochondrial mRNA synthesis in vivo. GF diets increased both the mRNA expression of factors involved in mitochondrial biogenesis, peroxisome proliferator-activated receptor gamma coactivator 1 alpha (PGC-1α), mitochondrial transcription factor A (Tfam), estrogen-related receptor alpha (ERRα), nuclear respiratory factor 1 (NRF-1), cytochrome c oxidase IV (COXIV) and ATP synthase (ATPsyn). Mice treated with GF diets showed an increase in running endurance, rotarod perseverance and grip strength when compared to controls who were on a regular diet. In addition, GF diets increased the protein expression of phosphorylated AMP-activated protein kinase (AMPK), sirtuin 1 (SIRT1), PGC-1α and peroxisome proliferator-activated receptor delta (PPAR-δ), which was greater than exercise-related changes. Finally, GF reduced the expression of phosphorylated ribosomal protein S6 kinase 1 (p-S6K1) and decreased autophagy. These results demonstrate that GF diets enhance exercise endurance, which is mediated via mitochondrial biogenesis and function. View Full-Text
Keywords: diet; endurance; mitochondrial biogenesis; autophagy diet; endurance; mitochondrial biogenesis; autophagy
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MDPI and ACS Style

Yu, J.; Zhu, H.; Taheri, S.; Perry, S.; Kindy, M.S. The Effect of Diet on Improved Endurance in Male C57BL/6 Mice. Nutrients 2018, 10, 1101.

AMA Style

Yu J, Zhu H, Taheri S, Perry S, Kindy MS. The Effect of Diet on Improved Endurance in Male C57BL/6 Mice. Nutrients. 2018; 10(8):1101.

Chicago/Turabian Style

Yu, Jin, Hong Zhu, Saeid Taheri, Stephen Perry, and Mark S. Kindy. 2018. "The Effect of Diet on Improved Endurance in Male C57BL/6 Mice" Nutrients 10, no. 8: 1101.

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