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Differential Effects of High Sugar, High Lard or a Combination of Both on Nutritional, Hormonal and Cardiovascular Metabolic Profiles of Rodents

1
Postgraduate Program in Nutrition and Health, Center of Health Sciences, Federal University of Espírito Santo, Vitória 29075-910, Espírito Santo, Brazil
2
Postgraduate Program in Physical Education, Center of Physical Education and Sports, Federal University of Espírito Santo (UFES), Vitória 29075-910, Espírito Santo, Brazil
3
University of Vila Velha, Vila Velha 29102-920, Espírito Santo, Brazil
4
Department of Sports, Center of Physical Education and Sports, Federal University of Espírito Santo, Vitória 29075-910, Espírito Santo, Brazil
*
Author to whom correspondence should be addressed.
Nutrients 2018, 10(8), 1071; https://doi.org/10.3390/nu10081071
Received: 8 July 2018 / Revised: 3 August 2018 / Accepted: 8 August 2018 / Published: 11 August 2018
Background: Dietary interventions in rodents can induce an excess of adipose tissue and metabolic disorders that resemble human obesity. Nevertheless, these approaches are not standardized, and the phenotypes may vary distinctly among studies. The aim of this study was to investigate the effects of different dietary interventions on nutritional, metabolic, biochemical, hormonal, and cardiovascular profiles, as well as to add to development and characterization of an experimental model of obesity. Methods: Male Wistar rats were randomized into four groups: control diet (C), high-sugar (HS), high-fat (HF), or high-sugar and high-fat (HFHS). Weekly measurements of body weight, adiposity, area under the curve (AUC) for glucose, blood pressure (BP) and serum triglycerides, total cholesterol level, and leptin were performed. Results: HF and HFHS models were led to obesity by increases in adipose tissue deposition and the adiposity index. All hypercaloric diets presented systolic BP increases. In addition, the AUC for glucose was greater in HF and HFHS than in C, and only the HF group presented hyperleptinemia. Conclusions: HF and HFHS diet approaches promote obesity and comorbidities, and thus represent a useful tool for studying human obesity-related disorders. By contrast, the HS model did not prove to be a good model of obesity. View Full-Text
Keywords: obesity; comorbidities; hypercaloric diets; experimental model; rodents obesity; comorbidities; hypercaloric diets; experimental model; rodents
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Matias, A.M.; Estevam, W.M.; Coelho, P.M.; Haese, D.; Kobi, J.B.B.S.; Lima-Leopoldo, A.P.; Leopoldo, A.S. Differential Effects of High Sugar, High Lard or a Combination of Both on Nutritional, Hormonal and Cardiovascular Metabolic Profiles of Rodents. Nutrients 2018, 10, 1071.

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