Nutritional Metabolomics: Postprandial Response of Meals Relating to Vegan, Lacto-Ovo Vegetarian, and Omnivore Diets
by
Millie Rådjursöga 1,*
, Helen M. Lindqvist 1, Anders Pedersen 2, B. Göran Karlsson 2, Daniel Malmodin 2, Lars Ellegård 1 and Anna Winkvist 1
Millie Rådjursöga 1,*, Helen M. Lindqvist 1, Anders Pedersen 2, B. Göran Karlsson 2, Daniel Malmodin 2, Lars Ellegård 1 and Anna Winkvist 1
1
Department of Internal Medicine and Clinical Nutrition, Sahlgrenska Academy, University of Gothenburg, Box 459, 405 30 Gothenburg, Sweden
2
Swedish NMR Centre, University of Gothenburg, Box 465, 405 30 Gothenburg, Sweden
*
Author to whom correspondence should be addressed.
Nutrients 2018, 10(8), 1063; https://doi.org/10.3390/nu10081063
Received: 29 June 2018 / Revised: 26 July 2018 / Accepted: 6 August 2018 / Published: 10 August 2018
Metabolomics provide an unbiased tool for exploring the modulation of the human metabolome in response to food intake. This study applied metabolomics to capture the postprandial metabolic response to breakfast meals corresponding to vegan (VE), lacto ovo-vegetarian (LOV), and omnivore (OM) diets. In a cross over design 32 healthy volunteers (16 men and 16 females) consumed breakfast meals in a randomized order during three consecutive days. Fasting and 3 h postprandial serum samples were collected and then subjected to metabolite profiling using 1H-nuclear magnetic resonance (NMR) spectroscopy. Changes in concentration of identified and discriminating metabolites, between fasting and postprandial state, were compared across meals. Betaine, choline, and creatine displayed higher concentration in the OM breakfast, while 3-hydroxyisobutyrate, carnitine, proline, and tyrosine showed an increase for the LOV and unidentified free fatty acids displayed a higher concentration after the VE breakfast. Using 1H NMR metabolomics it was possible to detect and distinguish the metabolic response of three different breakfast meals corresponding to vegan, lacto-ovo vegetarian, and omnivore diets in serum.
View Full-Text
Keywords:
metabolomics; nutrition; NMR; human metabolome; postprandial; serum; vegan; vegetarian; omnivore; diets
▼
Show Figures
Figure 1
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited
MDPI and ACS Style
Rådjursöga, M.; Lindqvist, H.M.; Pedersen, A.; Karlsson, B.G.; Malmodin, D.; Ellegård, L.; Winkvist, A. Nutritional Metabolomics: Postprandial Response of Meals Relating to Vegan, Lacto-Ovo Vegetarian, and Omnivore Diets. Nutrients 2018, 10, 1063.
Show more citation formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.
- Supplementary File 1:
ZIP-Document (ZIP, 330 KB)
