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Nutrients 2018, 10(7), 845; https://doi.org/10.3390/nu10070845

Effectiveness of Essence of Chicken on Cognitive Function Improvement: A Randomized Controlled Clinical Trial

1
Faculty of Psychology, Chulalongkorn University, Bangkok 10330, Thailand
2
Faculty of Medicine, Chulalongkorn University, Bangkok 10330, Thailand
*
Author to whom correspondence should be addressed.
Received: 18 May 2018 / Revised: 16 June 2018 / Accepted: 26 June 2018 / Published: 29 June 2018
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Abstract

High-quality, adequately-powered clinical trials investigating the effect of Essence of Chicken (EC) on cognitive function are lacking. We conducted a randomized, double-blind, placebo-controlled clinical trial on healthy adult volunteers to determine the effect of EC on short-term memory, working memory, and selective and sustained attention. As a secondary objective, we evaluated baseline stress as a modifying factor by including treatment, stress and visit as main effects in a three-way ANOVA model. Cognitive function was evaluated at baseline, and Days 7 and 14. Data from 235 participants were analyzed on a per-protocol basis. The three-way interaction effect was significant (p = 0.020) in Digit Span Forward and further analyses showed EC improved test performance in moderate (p = 0.041) and severe stress (p = 0.065) but not in normal and mild stress subgroups. In Digit Span Backward, EC group showed greater improvement compared to placebo (p = 0.028), with 0.60 digits (8.50% improvement from baseline) more recalled on Day 7. No treatment or interaction effects were statistically significant in selective and sustained attention tests. Our findings support EC’s effect in improving mental processes used in working memory among healthy adults and short-term memory among healthy adults experiencing stress in daily life. View Full-Text
Keywords: essence of chicken; chicken extract; chicken essence; health-nutritional supplement; cognitive function; stress; memory; working memory; short-term memory; attention essence of chicken; chicken extract; chicken essence; health-nutritional supplement; cognitive function; stress; memory; working memory; short-term memory; attention
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).
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Suttiwan, P.; Yuktanandana, P.; Ngamake, S. Effectiveness of Essence of Chicken on Cognitive Function Improvement: A Randomized Controlled Clinical Trial. Nutrients 2018, 10, 845.

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