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Open AccessArticle

Aluminum Exposure from Parenteral Nutrition: Early Bile Canaliculus Changes of the Hepatocyte

1
Department of Surgery, University of Saskatchewan, Saskatoon, SK S7N 5A2, Canada
2
Department of Community Health & Epidemiology, University of Saskatchewan, Saskatoon, SK S7N 5A2, Canada
3
College of Pharmacy and Nutrition, University of Saskatchewan, Saskatoon, SK S7N 5A2, Canada
4
Department of Biochemistry, Memorial University of Newfoundland, St. John’s, NL A1B 3X9, Canada
5
Department of Lab. Medicine and Pathology, University of Alberta, Edmonton, AB T6G 2B7, Canada
6
Department of Pediatrics, Stollery Children’s Hospital, Edmonton, AB T6G 2B7, Canada
*
Author to whom correspondence should be addressed.
Nutrients 2018, 10(6), 723; https://doi.org/10.3390/nu10060723
Received: 10 May 2018 / Revised: 27 May 2018 / Accepted: 1 June 2018 / Published: 4 June 2018
(This article belongs to the Special Issue Advances in Parenteral Nutrition)
Background: Neonates on long-term parenteral nutrition (PN) may develop parenteral nutrition-associated liver disease (PNALD). Aluminum (Al) is a known contaminant of infant PN, and we hypothesize that it substantially contributes to PNALD. In this study, we aim to assess the impact of Al on hepatocytes in a piglet model. Methods: We conducted a randomized control trial using a Yucatan piglet PN model. Piglets, aged 3–6 days, were placed into two groups. The high Al group (n = 8) received PN with 63 µg/kg/day of Al, while the low Al group (n = 7) received PN with 24 µg/kg/day of Al. Serum samples for total bile acids (TBA) were collected over two weeks, and liver tissue was obtained at the end of the experiment. Bile canaliculus morphometry were studied by transmission electron microscopy (TEM) and ImageJ software analysis. Results: The canalicular space was smaller and the microvilli were shorter in the high Al group than in the low Al group. There was no difference in the TBA between the groups. Conclusions: Al causes structural changes in the hepatocytes despite unaltered serum bile acids. High Al in PN is associated with short microvilli, which could decrease the functional excretion area of the hepatocytes and impair bile flow. View Full-Text
Keywords: aluminum; exposure; parenteral; toxicity; liver; canaliculus aluminum; exposure; parenteral; toxicity; liver; canaliculus
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MDPI and ACS Style

Hall, A.R.; Le, H.; Arnold, C.; Brunton, J.; Bertolo, R.; Miller, G.G.; Zello, G.A.; Sergi, C. Aluminum Exposure from Parenteral Nutrition: Early Bile Canaliculus Changes of the Hepatocyte. Nutrients 2018, 10, 723.

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