Combining Short-Term Interval Training with Caloric Restriction Improves ß-Cell Function in Obese Adults
AbstractAlthough low-calorie diets (LCD) improve glucose regulation, it is unclear if interval exercise (INT) is additive. We examined the impact of an LCD versus LCD + INT training on ß-cell function in relation to glucose tolerance in obese adults. Twenty-six adults (Age: 46 ± 12 year; BMI 38 ± 6 kg/m2) were randomized to 2-week of LCD (~1200 kcal/day) or energy-matched LCD + INT (60 min/day alternating 3 min at 90 and 50% HRpeak). A 2 h 75 g oral glucose tolerance test (OGTT) was performed. Insulin secretion rates (ISR) were determined by deconvolution modeling to assess glucose-stimulated insulin secretion ([GSIS: ISR/glucose total area under the curve (tAUC)]) and ß-cell function (Disposition Index [DI: GSIS/IR]) relative to skeletal muscle (Matsuda Index), hepatic (HOMA-IR) and adipose (Adipose-IRfasting) insulin resistance (IR). LCD + INT, but not LCD alone, reduced glucose and total-phase ISR tAUC (Interactions: p = 0.04 and p = 0.05, respectively). Both interventions improved skeletal muscle IR by 16% (p = 0.04) and skeletal muscle and hepatic DI (Time: p < 0.05). Improved skeletal muscle DI was associated with lower glucose tAUC (r = −0.57, p < 0.01). Thus, LCD + INT improved glucose tolerance more than LCD in obese adults, and these findings relate to ß-cell function. These data support LCD + INT for preserving pancreatic function for type 2 diabetes prevention. View Full-Text
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Francois, M.E.; Gilbertson, N.M.; Eichner, N.Z.M.; Heiston, E.M.; Fabris, C.; Breton, M.; Mehaffey, J.H.; Hassinger, T.; Hallowell, P.T.; Malin, S.K. Combining Short-Term Interval Training with Caloric Restriction Improves ß-Cell Function in Obese Adults. Nutrients 2018, 10, 717.
Francois ME, Gilbertson NM, Eichner NZM, Heiston EM, Fabris C, Breton M, Mehaffey JH, Hassinger T, Hallowell PT, Malin SK. Combining Short-Term Interval Training with Caloric Restriction Improves ß-Cell Function in Obese Adults. Nutrients. 2018; 10(6):717.Chicago/Turabian Style
Francois, Monique E.; Gilbertson, Nicole M.; Eichner, Natalie Z.M.; Heiston, Emily M.; Fabris, Chiara; Breton, Marc; Mehaffey, J. H.; Hassinger, Taryn; Hallowell, Peter T.; Malin, Steven K. 2018. "Combining Short-Term Interval Training with Caloric Restriction Improves ß-Cell Function in Obese Adults." Nutrients 10, no. 6: 717.
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