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Nutrients 2018, 10(5), 637;

A Phosphatidylserine Source of Docosahexanoic Acid Improves Neurodevelopment and Survival of Preterm Pigs

School of Health Studies, University of Memphis, Memphis, TN 38152, USA
Department of Anatomy and Neurobiology, College of Medicine, University of Tennessee Health Sciences Center, Memphis, TN 38163, USA
Department of Psychology, University of Memphis, Memphis, TN 38152, USA
Department of Behavioral Sciences, Christian Brothers University, Memphis, TN 38104, USA
Department of Neurobiology, Tel Aviv University, Tel Aviv 6997801, Israel
Department of Biological Sciences, University of Memphis, Memphis, TN 38152, USA
Enzymotec, Sagi 2000 Industrial Park, Migdal HaEmeq 23106, Israel
Author to whom correspondence should be addressed.
Received: 29 March 2018 / Revised: 2 May 2018 / Accepted: 14 May 2018 / Published: 18 May 2018
(This article belongs to the Special Issue Early Life Nutrition: From Nutrients to Systems)
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The amount, composition, and sources of nutrition support provided to preterm infants is critical for normal growth and development, and particularly for structural and functional neurodevelopment. Although omega-3 long chain polyunsaturated fatty acids (LC-PUFA), and particularly docosahexanoic acid (DHA), are considered of particular importance, results from clinical trials with preterm infants have been inconclusive because of ethical limitations and confounding variables. A translational large animal model is needed to understand the structural and functional responses to DHA. Neurodevelopment of preterm pigs was evaluated in response to feeding formulas to term-equivalent age supplemented with DHA attached to phosphatidylserine (PS-DHA) or sunflower oil as the placebo. Newborn term pigs were used as a control for normal in utero neurodevelopment. Supplementing formula with PS-DHA increased weight of the brain, and particularly the cerebellum, at term-equivalent age compared with placebo preterm pigs (P’s < 0.10 and 0.05 respectively), with a higher degree of myelination in all regions of the brain examined (all p < 0.06). Brains of pigs provided PS-DHA were similar in weight to newborn term pigs. Event-related brain potentials and performance in a novel object recognition test indicated the PS-DHA supplement accelerated development of sensory pathways and recognition memory compared with placebo preterm pigs. The PS-DHA did not increase weight gain, but was associated with higher survival. The benefits of PS-DHA include improving neurodevelopment and possibly improvement of survival, and justify further studies to define dose-response relations, compare benefits associated with other sources of DHA, and understand the mechanisms underlying the benefits and influences on the development of other tissues and organ systems. View Full-Text
Keywords: prematurity; preterm infant; docosahexanoic acid; phosphatidylserine; brain; neurodevelopment prematurity; preterm infant; docosahexanoic acid; phosphatidylserine; brain; neurodevelopment
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Buddington, R.K.; Chizhikov, V.V.; Iskusnykh, I.Y.; Sable, H.J.; Sable, J.J.; Holloway, Z.R.; Blumenfeld Katzir, T.; van der Merwe, M.; Yakimkova, T.; Buddington, K.K.; Lifshitz, Y.; Tessler, S.; Gilbert, A. A Phosphatidylserine Source of Docosahexanoic Acid Improves Neurodevelopment and Survival of Preterm Pigs. Nutrients 2018, 10, 637.

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