Microbiome Responses to an Uncontrolled Short-Term Diet Intervention in the Frame of the Citizen Science Project
AbstractPersonalized nutrition is of increasing interest to individuals actively monitoring their health. The relations between the duration of diet intervention and the effects on gut microbiota have yet to be elucidated. Here we examined the associations of short-term dietary changes, long-term dietary habits and lifestyle with gut microbiota. Stool samples from 248 citizen-science volunteers were collected before and after a self-reported 2-week personalized diet intervention, then analyzed using 16S rRNA sequencing. Considerable correlations between long-term dietary habits and gut community structure were detected. A higher intake of vegetables and fruits was associated with increased levels of butyrate-producing Clostridiales and higher community richness. A paired comparison of the metagenomes before and after the 2-week intervention showed that even a brief, uncontrolled intervention produced profound changes in community structure: resulting in decreased levels of Bacteroidaceae, Porphyromonadaceae and Rikenellaceae families and decreased alpha-diversity coupled with an increase of Methanobrevibacter, Bifidobacterium, Clostridium and butyrate-producing Lachnospiraceae- as well as the prevalence of a permatype (a bootstrapping-based variation of enterotype) associated with a higher diversity of diet. The response of microbiota to the intervention was dependent on the initial microbiota state. These findings pave the way for the development of an individualized diet. View Full-Text
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Klimenko, N.S.; Tyakht, A.V.; Popenko, A.S.; Vasiliev, A.S.; Altukhov, I.A.; Ischenko, D.S.; Shashkova, T.I.; Efimova, D.A.; Nikogosov, D.A.; Osipenko, D.A.; Musienko, S.V.; Selezneva, K.S.; Baranova, A.; Kurilshikov, A.M.; Toshchakov, S.M.; Korzhenkov, A.A.; Samarov, N.I.; Shevchenko, M.A.; Tepliuk, A.V.; Alexeev, D.G. Microbiome Responses to an Uncontrolled Short-Term Diet Intervention in the Frame of the Citizen Science Project. Nutrients 2018, 10, 576.
Klimenko NS, Tyakht AV, Popenko AS, Vasiliev AS, Altukhov IA, Ischenko DS, Shashkova TI, Efimova DA, Nikogosov DA, Osipenko DA, Musienko SV, Selezneva KS, Baranova A, Kurilshikov AM, Toshchakov SM, Korzhenkov AA, Samarov NI, Shevchenko MA, Tepliuk AV, Alexeev DG. Microbiome Responses to an Uncontrolled Short-Term Diet Intervention in the Frame of the Citizen Science Project. Nutrients. 2018; 10(5):576.Chicago/Turabian Style
Klimenko, Natalia S.; Tyakht, Alexander V.; Popenko, Anna S.; Vasiliev, Anatoly S.; Altukhov, Ilya A.; Ischenko, Dmitry S.; Shashkova, Tatiana I.; Efimova, Daria A.; Nikogosov, Dmitri A.; Osipenko, Dmitrii A.; Musienko, Sergey V.; Selezneva, Kseniya S.; Baranova, Ancha; Kurilshikov, Alexander M.; Toshchakov, Stepan M.; Korzhenkov, Aleksei A.; Samarov, Nazar I.; Shevchenko, Margarita A.; Tepliuk, Alina V.; Alexeev, Dmitry G. 2018. "Microbiome Responses to an Uncontrolled Short-Term Diet Intervention in the Frame of the Citizen Science Project." Nutrients 10, no. 5: 576.
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