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Anti-Diabetic Effects and Anti-Inflammatory Effects of Laminaria japonica and Hizikia fusiforme in Skeletal Muscle: In Vitro and In Vivo Model

1
Dietetics Team, Cheju Halla General Hospital, Jeju 63127, Korea
2
Department of Food Science and Nutrition, Jeju National University, Jeju 63243, Korea
3
Department of Food and Nutrition, Research Institute of Obesity Sciences, Sungshin Women’s University, Seoul 01133, Korea
*
Author to whom correspondence should be addressed.
Sae-ym Kang and Eunyoung Kim contributed equally to this study.
Current address: 9-423, Natural Science Building I, 102 Jejudaehak-ro, Jeju 63243, Korea.
Nutrients 2018, 10(4), 491; https://doi.org/10.3390/nu10040491
Received: 28 February 2018 / Revised: 13 April 2018 / Accepted: 13 April 2018 / Published: 16 April 2018
(This article belongs to the Special Issue Nutrients, Bioactives and Insulin Resistance)
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Abstract

Laminaria japonica (LJ) and Hizikia fusiforme (HF) are brown seaweeds known to have various health-promoting effects. In this study, we investigated the anti-diabetic effects and possible mechanism(s) of LJ and HF by using both in vitro and in vivo models. C2C12 myotubes, mouse-derived skeletal muscle cells, treated with LF or HF extracts were used for the in vitro model, and muscle tissues from C57BL/6N mice fed a high-fat diet supplemented with 5% LF or HF for 16 weeks were used for the in vivo model. Although both the LF and HF extracts significantly inhibited α-glucosidase activity in a dose-dependent manner, the HF extract had a superior α-glucosidase inhibition than the LF extract. In addition, glucose uptake was significantly increased by LJ- and HF-treated groups when compared to the control group. Phosphorylation of protein kinase B and AMP-activated protein kinase was induced by LJ and HF in both the vivo and in vitro skeletal muscle models. Furthermore, LJ and HF significantly decreased tumor necrosis factor-α whereas both extracts increased interleukin (IL)-6 and IL-10 production in lipopolysaccharide-stimulated C2C12 myotubes. Taken together, these findings imply that the brown seaweeds LJ and HF could be useful therapeutic agents to attenuate muscle insulin resistance due to diet-induced obesity and its associated inflammation. View Full-Text
Keywords: brown seaweeds; anti-diabetic; Laminaria japonica; Hizikia fusiforme; C2C12 cell; skeletal muscle brown seaweeds; anti-diabetic; Laminaria japonica; Hizikia fusiforme; C2C12 cell; skeletal muscle
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Kang, S.-Y.; Kim, E.; Kang, I.; Lee, M.; Lee, Y. Anti-Diabetic Effects and Anti-Inflammatory Effects of Laminaria japonica and Hizikia fusiforme in Skeletal Muscle: In Vitro and In Vivo Model. Nutrients 2018, 10, 491.

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