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Nutrients 2018, 10(4), 424; https://doi.org/10.3390/nu10040424

The Effects of Isoflavone Supplementation Plus Combined Exercise on Lipid Levels, and Inflammatory and Oxidative Stress Markers in Postmenopausal Women

1
Laboratory of Cardiorespiratory and Metabolic Physiology, Federal University of Uberlândia, Uberlândia-MG 38400-678, Brazil
2
Laboratory of Immunotechnology and Immunochemistry, Institute of Biomedical Sciences, Federal University of Uberlândia, Uberlândia-MG 38400-902, Brazil
3
Laboratory of Biochemistry and Molecular Biology, Institute of Biotechnology, Federal University of Uberlândia, Uberlândia-MG 38400-902, Brazil
4
School of Medicine, Federal University of Uberlândia, Uberlândia-MG 38400-902, Brazil
5
College of Graduate Health Studies, AT. Still University, Mesa, AZ 85206, USA
*
Author to whom correspondence should be addressed.
Received: 31 January 2018 / Revised: 8 March 2018 / Accepted: 21 March 2018 / Published: 29 March 2018
(This article belongs to the Special Issue Nutrition and Ageing)
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Abstract

This study tested the effect of isoflavone supplementation in addition to combined exercise training on plasma lipid levels, inflammatory markers and oxidative stress in postmenopausal women. Thirty-two healthy and non-obese postmenopausal women without hormone therapy were randomly assigned to exercise + placebo (PLA; n = 15) or exercise + isoflavone supplementation (ISO; n = 17) groups. They performed 30 sessions of combined exercises (aerobic plus resistance) over ten weeks and consumed 100 mg of isoflavone supplementation or placebo. Blood samples were collected after an overnight fast to analyze the lipid profile, interleukin-6 (IL-6), interleukin-8 (IL-8), superoxide dismutase (SOD), total antioxidant capacity (FRAP), and thiobarbituric acid reactive substances (TBARS), before and after ten weeks of the intervention. There were no differences in the changes (pre vs. post) between groups for any of the inflammatory markers, oxidative stress markers or lipid profile variables. However, interleukin-8 was different between pre- and post-tests (p < 0.001) in both groups (Δ = 7.61 and 5.61 pg/mL) as were cholesterol levels (p < 0.05), with no interaction between groups. The combination of isoflavone supplementation and exercise training did not alter oxidative stress markers in postmenopausal women, but exercise training alone may increase IL-8 and decrease total cholesterol levels. View Full-Text
Keywords: aerobic and resistance exercises; soy protein; menopause; cytokines; anti-oxidant system aerobic and resistance exercises; soy protein; menopause; cytokines; anti-oxidant system
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Giolo, J.S.; Costa, J.G.; Da Cunha-Junior, J.P.; Pajuaba, A.C.A.M.; Taketomi, E.A.; De Souza, A.V.; Caixeta, D.C.; Peixoto, L.G.; De Oliveira, E.P.; Everman, S.; Espindola, F.S.; Puga, G.M. The Effects of Isoflavone Supplementation Plus Combined Exercise on Lipid Levels, and Inflammatory and Oxidative Stress Markers in Postmenopausal Women. Nutrients 2018, 10, 424.

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