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Bioactive Dietary VDR Ligands Regulate Genes Encoding Biomarkers of Skin Repair That Are Associated with Risk for Psoriasis

Nutraceuticals for Skin Care: A Comprehensive Review of Human Clinical Studies

Instituto de Biología Molecular y Celular (IBMC), Universidad Miguel Hernández (UMH), Edificio Torregaitán, 03202 Elche, Spain
Ilice Effitech, UMH Scientific Park, 03202 Elche, Spain
CIBER: CB12/03/30038, Fisiopatología de la Obesidad y la Nutrición, CIBERobn, Instituto de Salud Carlos III (ISCIII), 07122 Palma Sola, Spain
Author to whom correspondence should be addressed.
Nutrients 2018, 10(4), 403;
Received: 12 February 2018 / Revised: 20 March 2018 / Accepted: 21 March 2018 / Published: 24 March 2018
(This article belongs to the Special Issue Nutraceuticals and the Skin: Roles in Health and Disease)
The skin is the body’s largest organ, it participates in sensitivity and offers protection against microorganisms, chemicals and ultraviolet (UV) radiation. Consequently, the skin may suffer alterations such as photo-ageing, immune dysfunction and inflammation which may significantly affect human health. Nutraceuticals represent a promising strategy for preventing, delaying, or minimising premature ageing of the skin and also to alleviate certain skin disorders. Among them, bioactive peptides and oligosaccharides, plant polyphenols, carotenoids, vitamins and polyunsaturated fatty acids are the most widely used ingredients. Supplementation with these products has shown evidence of having an effect on the signs of ageing and protection against UV radiation ageing in several human trials. In this review, the most relevant human studies on skin nutraceuticals are evaluated and the statistical resolution, biological relevance of their results, and, the trial protocols are discussed. In conclusion, quality and rigorousness of the trials must be improved to build credible scientific evidence for skin nutraceuticals and to establish a cause-effect relationship between the ingredients the beneficial effects for the skin. View Full-Text
Keywords: nutraceutical; skin; natural compound; polyphenols nutraceutical; skin; natural compound; polyphenols
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MDPI and ACS Style

Pérez-Sánchez, A.; Barrajón-Catalán, E.; Herranz-López, M.; Micol, V. Nutraceuticals for Skin Care: A Comprehensive Review of Human Clinical Studies. Nutrients 2018, 10, 403.

AMA Style

Pérez-Sánchez A, Barrajón-Catalán E, Herranz-López M, Micol V. Nutraceuticals for Skin Care: A Comprehensive Review of Human Clinical Studies. Nutrients. 2018; 10(4):403.

Chicago/Turabian Style

Pérez-Sánchez, Almudena, Enrique Barrajón-Catalán, María Herranz-López, and Vicente Micol. 2018. "Nutraceuticals for Skin Care: A Comprehensive Review of Human Clinical Studies" Nutrients 10, no. 4: 403.

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