Sucrosomial Iron Supplementation in Anemic Patients with Celiac Disease Not Tolerating Oral Ferrous Sulfate: A Prospective Study
Abstract
:1. Introduction
2. Patients and Methods
2.1. Study Setting and Design
2.2. Evaluations
2.3. Statistical Analysis
3. Results
3.1. Patient Populations
3.2. Iron Parameters
3.3. Effects in Patients with Mucosal Damage
3.4. Symptoms and Tolerability
4. Discussion
5. Conclusions
Acknowledgments
Author Contributions
Conflicts of Interest
References
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Patients’ Characteristics | Sucrosomial Iron Group (n = 24) | Iron Sulfate Group (n = 19) | p |
---|---|---|---|
Sex (n, male/female) | 1/23 | 1/18 | 1.00 |
Age at enrollment (years) | 43 ± 10 | 40 ± 8 | 0.22 |
Age at diagnosis (years) | 38 ± 8 | 31 ± 12 | 0.06 |
GFD duration (years) | 6 ± 5 | 9 ± 9 | 0.26 |
BMI | 21 ± 2 | 22 ± 3 | 0.34 |
Smokers, n (%) | 0 (0%) | 2 (16%) | 0.08 |
Menstrual cycle duration (days) | 5 ± 2 | 4 ± 2 | 0.20 |
Tampons, n | 26 ± 17 | 21 ± 13 | 0.28 |
Hp positivity, n (%) | 2 (8%) | 2 (10%) | 1.00 |
Colonoscopy | 16 | 7 | 0.051 |
MARSH Grade, n (%) | 22 (92%) | 17 (89%) | 0.13 |
0 | 7 (32%) | 7 (41%) | |
1 | 6 (27%) | 2 (12%) | |
2 | - | 1 (6%) | |
3a | 5 (23%) | 5 (29%) | |
3b | 4 (18%) | - | |
3c | - | 2 (12%) | |
Comorbidities, n (%) | 9 (37.5%) | 5 (26%) | 0.44 |
Sucrosomial Iron Group (n = 23) | Iron Sulfate Group (n = 17) | ||||||||
---|---|---|---|---|---|---|---|---|---|
T0 | T45 | T90 | P(T0–T90) | T0 | T45 | T90 | P(T0–T90) | P(groups) | |
Hemoglobin (g/dL) | 10.9 ± 0.7 | 11.7 ± 0.7 | 12.0 ± 0.7 | 0.03 | 11.0 ± 1.0 | 12.2 ± 1.0 | 12.9 ± 1.1 | 0.002 | 0.03 |
MCV (fL) | 76.4 ± 5 | 81.1 ± 5.2 | 83.5 ± 5.0 | 0.002 | 74.2 ± 7.5 | 81.8 ± 7.3 | 83.7 ± 6.8 | 0.008 | 0.33 |
Hematocrit (%) | 34.2 ± 2.5 | 36.2 ± 2.9 | 36.7 ± 3.0 | 0.08 | 35.4 ± 3.9 | 37.6 ± 2.6 | 38.8 ± 2.6 | 0.008 | 0.06 |
Serum Iron (µg/dL) | 41.8 ± 24.0 | 59.0 ± 29.0 | 59.9 ± 35.4 | 0.8 | 44.9 ± 29.9 | 66.2 ± 28.0 | 73.2 ± 21.9 | 0.14 | 0.28 |
Ferritin (ng/mL) | 10.7 ± 12.4 | 16.2 ± 15.2 | 18.2 ± 15.7 | 0.04 | 13.4 ± 15.8 | 51.2 ± 82.4 | 59.1 ± 76.3 | 0.007 | 0.0001 |
Transferrin (mg/dL) | 311.5 ± 51.3 | 302.4 ± 46.6 | 292.1 ± 51.0 | 0.007 | 320.6 ± 50.5 | 293.0 ± 55.4 | 271.6 ± 40.7 | 0.006 | 0.2 |
Transferrin sat. (%) | 10.0 ± 6.4 | 14.8 ± 9.0 | 14.8 ± 8.2 | 0.8 | 10.6 ± 8.4 | 16.8 ± 8.0 | 19.6 ± 6.6 | 0.03 | 0.04 |
Sucrosomial Iron Group (n = 23) | Iron Sulfate Group (n = 17) | ||||||||
---|---|---|---|---|---|---|---|---|---|
T0 | T45 | T90 | P(T0–T90) | T0 | T45 | T90 | P(T0–T90) | P(groups) | |
Abdominal Pain | 1.9 ± 2.1 | 2.2 ± 2.2 | 2.2 ± 2.7 | 0.07 | 1.9 ± 1.6 | 2.7 ± 2.8 | 2.9 ± 2.5 | 0.07 | 0.52 |
Epigastric Pain | 1.8 ± 2.4 | 1.6 ± 2.4 | 1.3 ± 1.7 | 0.7 | 1.9 ± 2.1 | 2.4 ± 2.3 | 2.3 ± 1.8 | 0.7 | 0.31 |
Abdominal Bloating | 4.9 ± 3.1 | 4.4 ± 3.2 | 4.2 ± 3.5 | 0.9 | 3.7 ± 2.5 | 4.2 ± 3.1 | 4.1 ± 2.9 | 0.9 | 0.6 |
Diarrhea | 1.1 ± 1.6 | 2.3 ± 2.7 | 2.0 ± 2.3 | 0.12 | 1.5 ± 1.3 | 2.4 ± 2.0 | 2.3 ± 1.6 | 0.11 | 0.57 |
Constipation | 2.6 ± 3.0 | 2.0 ± 2.6 | 1.9 ± 2.8 | 0.5 | 2.0 ± 2.2 | 2.2 ± 2.5 | 2.8 ± 2.6 | 0.7 | 0.8 |
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Elli, L.; Ferretti, F.; Branchi, F.; Tomba, C.; Lombardo, V.; Scricciolo, A.; Doneda, L.; Roncoroni, L. Sucrosomial Iron Supplementation in Anemic Patients with Celiac Disease Not Tolerating Oral Ferrous Sulfate: A Prospective Study. Nutrients 2018, 10, 330. https://doi.org/10.3390/nu10030330
Elli L, Ferretti F, Branchi F, Tomba C, Lombardo V, Scricciolo A, Doneda L, Roncoroni L. Sucrosomial Iron Supplementation in Anemic Patients with Celiac Disease Not Tolerating Oral Ferrous Sulfate: A Prospective Study. Nutrients. 2018; 10(3):330. https://doi.org/10.3390/nu10030330
Chicago/Turabian StyleElli, Luca, Francesca Ferretti, Federica Branchi, Carolina Tomba, Vincenza Lombardo, Alice Scricciolo, Luisa Doneda, and Leda Roncoroni. 2018. "Sucrosomial Iron Supplementation in Anemic Patients with Celiac Disease Not Tolerating Oral Ferrous Sulfate: A Prospective Study" Nutrients 10, no. 3: 330. https://doi.org/10.3390/nu10030330
APA StyleElli, L., Ferretti, F., Branchi, F., Tomba, C., Lombardo, V., Scricciolo, A., Doneda, L., & Roncoroni, L. (2018). Sucrosomial Iron Supplementation in Anemic Patients with Celiac Disease Not Tolerating Oral Ferrous Sulfate: A Prospective Study. Nutrients, 10(3), 330. https://doi.org/10.3390/nu10030330