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Open AccessArticle

l-Glutamine Attenuates DSS-Induced Colitis via Induction of MAPK Phosphatase-1

Department of Biological Sciences, College of Natural Sciences, Chonnam National University, Gwangju 61186, Korea
Department of Immunology and Institute for Medical Science, Chonbuk National University Medical School, Jeonju 561-180, Korea
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Nutrients 2018, 10(3), 288;
Received: 23 October 2017 / Revised: 28 December 2017 / Accepted: 8 January 2018 / Published: 1 March 2018
Inflammatory bowel disease (IBD), encompassing ulcerative colitis and Crohn’s disease, is a multifactorial inflammatory disease of the small intestine and colon. Many investigators have reported that l-glutamine (Gln) therapy improves outcomes of experimental colitis models, although the mechanism is not fully understood. Regarding the anti-inflammatory properties of Gln, we have shown that Gln can effectively deactivate cytosolic phospholipase A2 (cPLA2) by rapid induction of MAPK phosphatase (MKP)-1. In this study, we explore the possibility that Gln ameliorates dextran sulfate sodium (DSS)-induced colitis via MKP-1 induction, resulting in inhibition of cPLA2, which has been reported to play a key role in the pathogenesis of IBD. Oral Gln intake attenuated DSS-induced colitis. Gln inhibited cPLA2 phosphorylation, as well as colonic levels of TNF-α and leukotriene (LT)B4. Gln administration resulted in early and enhanced MKP-1 induction. Importantly, MKP-1 small interfering RNA (siRNA), but not control siRNA, significantly abrogated the Gln-mediated (1) induction of MKP-1; (2) attenuation of colitis (colon length, histological abnormality, and inflammation; and (3) inhibition of cPLA2 phosphorylation and colonic levels of TNF-α and LTB4. These data indicated that Gln ameliorated DSS-induced colitis via MKP-1 induction. View Full-Text
Keywords: glutamine; inflammatory bowel disease; DSS; MKP-1; cPLA2 glutamine; inflammatory bowel disease; DSS; MKP-1; cPLA2
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Jeong, S.-Y.; Im, Y.N.; Youm, J.Y.; Lee, H.-K.; Im, S.-Y. l-Glutamine Attenuates DSS-Induced Colitis via Induction of MAPK Phosphatase-1. Nutrients 2018, 10, 288.

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