Next Article in Journal
Eucommia ulmoides Ameliorates Glucotoxicity by Suppressing Advanced Glycation End-Products in Diabetic Mice Kidney
Previous Article in Journal
Lead Affects Vitamin D Metabolism in Rats
Article Menu
Issue 3 (March) cover image

Export Article

Open AccessArticle
Nutrients 2018, 10(3), 266; https://doi.org/10.3390/nu10030266

Impact of Genetic Variants on the Individual Potential for Body Fat Loss

1
Samsung Genome Institute, Samsung Medical Center, Gangnam-gu, Seoul 06351, Korea
2
Department of Molecular Cell Biology, Sungkyunkwan University School of Medicine, Suwon 16419, Gyeonggi-do, Korea
3
Software R&D Center, Samsung Electronics, Hwaseong 18448, Gyeonggi-do, Korea
4
Department of Food and Nutrition, Dongduk Women’s University, Seoul 02748, Korea
*
Authors to whom correspondence should be addressed.
Received: 7 December 2017 / Revised: 9 February 2018 / Accepted: 23 February 2018 / Published: 26 February 2018
  |  
PDF [2845 KB, uploaded 26 February 2018]
  |  

Abstract

The past decade has witnessed the discovery of obesity-related genetic variants and their functions through genome-wide association studies. Combinations of risk alleles can influence obesity phenotypes with different degrees of effectiveness across various individuals by interacting with environmental factors. We examined the interaction between genetic variation and changes in dietary habits or exercise that influences body fat loss from a large Korean cohort (n = 8840). Out of 673 obesity-related SNPs, a total of 100 SNPs (37 for carbohydrate intake; 19 for fat intake; 44 for total calories intake; 25 for exercise onset) identified to have gene-environment interaction effect in generalized linear model were used to calculate genetic risk scores (GRS). Based on the GRS distribution, we divided the population into four levels, namely, “very insensitive”, “insensitive”, “sensitive”, and “very sensitive” for each of the four categories, “carbohydrate intake”, “fat intake”, “total calories intake”, and “exercise”. Overall, the mean body fat loss became larger when the sensitivity level was increased. In conclusion, genetic variants influence the effectiveness of dietary regimes for body fat loss. Based on our findings, we suggest a platform for personalized body fat management by providing the most suitable and effective nutrition or activity plan specific to an individual. View Full-Text
Keywords: GWAS; BMI; body fat; obesity; diet; health; exercise; genetic risk score GWAS; BMI; body fat; obesity; diet; health; exercise; genetic risk score
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

Supplementary material

SciFeed

Share & Cite This Article

MDPI and ACS Style

Cha, S.; Kang, J.H.; Lee, J.-H.; Kim, J.; Kim, H.; Yang, Y.J.; Park, W.-Y.; Kim, J. Impact of Genetic Variants on the Individual Potential for Body Fat Loss. Nutrients 2018, 10, 266.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Nutrients EISSN 2072-6643 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top