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Impact of Genetic Variants on the Individual Potential for Body Fat Loss

Samsung Genome Institute, Samsung Medical Center, Gangnam-gu, Seoul 06351, Korea
Department of Molecular Cell Biology, Sungkyunkwan University School of Medicine, Suwon 16419, Gyeonggi-do, Korea
Software R&D Center, Samsung Electronics, Hwaseong 18448, Gyeonggi-do, Korea
Department of Food and Nutrition, Dongduk Women’s University, Seoul 02748, Korea
Authors to whom correspondence should be addressed.
Nutrients 2018, 10(3), 266;
Received: 7 December 2017 / Revised: 9 February 2018 / Accepted: 23 February 2018 / Published: 26 February 2018
The past decade has witnessed the discovery of obesity-related genetic variants and their functions through genome-wide association studies. Combinations of risk alleles can influence obesity phenotypes with different degrees of effectiveness across various individuals by interacting with environmental factors. We examined the interaction between genetic variation and changes in dietary habits or exercise that influences body fat loss from a large Korean cohort (n = 8840). Out of 673 obesity-related SNPs, a total of 100 SNPs (37 for carbohydrate intake; 19 for fat intake; 44 for total calories intake; 25 for exercise onset) identified to have gene-environment interaction effect in generalized linear model were used to calculate genetic risk scores (GRS). Based on the GRS distribution, we divided the population into four levels, namely, “very insensitive”, “insensitive”, “sensitive”, and “very sensitive” for each of the four categories, “carbohydrate intake”, “fat intake”, “total calories intake”, and “exercise”. Overall, the mean body fat loss became larger when the sensitivity level was increased. In conclusion, genetic variants influence the effectiveness of dietary regimes for body fat loss. Based on our findings, we suggest a platform for personalized body fat management by providing the most suitable and effective nutrition or activity plan specific to an individual. View Full-Text
Keywords: GWAS; BMI; body fat; obesity; diet; health; exercise; genetic risk score GWAS; BMI; body fat; obesity; diet; health; exercise; genetic risk score
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Cha, S.; Kang, J.H.; Lee, J.-H.; Kim, J.; Kim, H.; Yang, Y.J.; Park, W.-Y.; Kim, J. Impact of Genetic Variants on the Individual Potential for Body Fat Loss. Nutrients 2018, 10, 266.

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