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Zinc and Skin Disorders
Open AccessReview

The Role of the Slc39a Family of Zinc Transporters in Zinc Homeostasis in Skin

Division of Pathology, Department of Oral Diagnostic Sciences, School of Dentistry, Showa University, Tokyo 142-8555, Japan
Osteoimmunology, Deutsches Rheuma-Forschungszentrum, 10117 Berlin, Germany
AmorePacific Corporation R&D Center, Yongin, Gyeonggi-do 446-729, Korea
Faculty of Pharmaceutical Sciences, Tokushima Bunri University, Tokushima 770-8055, Japan
RIKEN Center for Integrative Medical Sciences, Yokohama 230-0042, Japan
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Nutrients 2018, 10(2), 219;
Received: 20 December 2017 / Revised: 27 January 2018 / Accepted: 11 February 2018 / Published: 16 February 2018
(This article belongs to the Special Issue Dietary Zn and Human Health)
The first manifestations that appear under zinc deficiency are skin defects such as dermatitis, alopecia, acne, eczema, dry, and scaling skin. Several genetic disorders including acrodermatitis enteropathica (also known as Danbolt-Closs syndrome) and Brandt’s syndrome are highly related to zinc deficiency. However, the zinc-related molecular mechanisms underlying normal skin development and homeostasis, as well as the mechanism by which disturbed zinc homeostasis causes such skin disorders, are unknown. Recent genomic approaches have revealed the physiological importance of zinc transporters in skin formation and clarified their functional impairment in cutaneous pathogenesis. In this review, we provide an overview of the relationships between zinc deficiency and skin disorders, focusing on the roles of zinc transporters in the skin. We also discuss therapeutic outlooks and advantages of controlling zinc levels via zinc transporters to prevent cutaneous disorganization. View Full-Text
Keywords: zinc; skin; homeostasis; transporter zinc; skin; homeostasis; transporter
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Bin, B.-H.; Hojyo, S.; Seo, J.; Hara, T.; Takagishi, T.; Mishima, K.; Fukada, T. The Role of the Slc39a Family of Zinc Transporters in Zinc Homeostasis in Skin. Nutrients 2018, 10, 219.

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