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Article

Vitamin D Daily versus Monthly Administration: Bone Turnover and Adipose Tissue Influences

1
Clinic of Internal Medicine, Section D, Department of Medicine, University of Verona, 37134 Verona, Italy
2
Specialized Regional Center for Biomolecular and Histomorphometric Research for Skeletal and Degenerative Diseases, 37134 Verona, Italy
3
Department of Surgical Sciences, Dentistry, Gynecology and Pediatrics, Pediatric Division, University of Verona, 37134 Verona, Italy
4
Pennington Biomedical Research Center, Baton Rouge, LA 70808, USA
*
Author to whom correspondence should be addressed.
Nutrients 2018, 10(12), 1934; https://doi.org/10.3390/nu10121934
Received: 19 November 2018 / Revised: 3 December 2018 / Accepted: 3 December 2018 / Published: 6 December 2018
Vitamin D is involved in bone metabolism and in many various extra-skeletal diseases such as malabsorption syndromes, cardiovascular and metabolic diseases, cancer, and autoimmune and neurological diseases. However, data on the optimal route of administration are not consistent. The aims of our study were to analyze not only the influence of daily vs. monthly administration of vitamin D on bone metabolism and bone turnover, but also the effects of different routes of administration on fat mass in a cohort of adults with low levels of 25(OH) vitamin D3 at baseline. We analyzed 44 patients with hypovitaminosis at baseline and after six months of two different regimens of administration: seven drops (1750 IU)/day vs. 50,000 IU/month. We found that the two regimens were equivalent; 36 out of 44 patients reached the normal range of vitamin D after six months of treatment. Interestingly, the main determinant of vitamin D at baseline was the waist circumference. In addition, 22 patients treated by monthly regimen were evaluated after 18 months of treatment. At the end of follow-up, patients showed normal levels of vitamin D, with increased calcium levels and decreased bone turnover. Waist circumference also decreased. Our results support the efficacy of vitamin D3 given monthly both for correcting hypovitaminosis and for maintaining vitamin D levels. The relationship between serum 25(OH)vitamin D3 concentration and waist circumference supports vitamin D having a protective role in the current setting, since waist size is directly associated with the risk of cardiovascular and metabolic diseases. View Full-Text
Keywords: adipose tissue; dosage; waist circumference; monthly; vitamin D adipose tissue; dosage; waist circumference; monthly; vitamin D
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MDPI and ACS Style

Dalle Carbonare, L.; Valenti, M.T.; Del Forno, F.; Piacentini, G.; Pietrobelli, A. Vitamin D Daily versus Monthly Administration: Bone Turnover and Adipose Tissue Influences. Nutrients 2018, 10, 1934. https://doi.org/10.3390/nu10121934

AMA Style

Dalle Carbonare L, Valenti MT, Del Forno F, Piacentini G, Pietrobelli A. Vitamin D Daily versus Monthly Administration: Bone Turnover and Adipose Tissue Influences. Nutrients. 2018; 10(12):1934. https://doi.org/10.3390/nu10121934

Chicago/Turabian Style

Dalle Carbonare, Luca, Maria T. Valenti, Francesco Del Forno, Giorgio Piacentini, and Angelo Pietrobelli. 2018. "Vitamin D Daily versus Monthly Administration: Bone Turnover and Adipose Tissue Influences" Nutrients 10, no. 12: 1934. https://doi.org/10.3390/nu10121934

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