Lisosan G Protects the Retina from Neurovascular Damage in Experimental Diabetic Retinopathy
AbstractLisosan G (LG), a fermented powder obtained from whole grains, is a recognized antioxidant compound that improves the bioactivity and survival of different cell types. The purpose of this study was to investigate whether LG ameliorates both the neural and the vascular damage characterizing early stages of diabetic retinopathy (DR). The effects of LG were studied in cultured explants of mouse retinas challenged with oxidative stress (OS) or in retinas of streptozotocin (STZ)-treated rats. Apoptosis, vascular endothelial growth factor (VEGF) expression, OS markers, blood-retinal barrier (BRB) integrity, and inflammation were assessed, while retinal function was evaluated with electroretinogram (ERG). LG extensively inhibited apoptosis, VEGF expression, and OS both in retinal explants and in STZ rats. In addition, STZ rats treated with LG displayed an almost total BRB integrity, reduced levels of inflammatory markers and a partially restored visual function as evaluated with ERG. In summary, we demonstrated that LG exhibits antioxidant and anti-inflammatory effects that exert powerful protective actions against neural and vascular defects characteristic of DR. Therefore, LG-containing foods or supplements may be considered to implement DR treatments.
- Supplementary File 1:
Supplementary (PDF, 109 KB)
Share & Cite This Article
Amato, R.; Rossino, M.G.; Cammalleri, M.; Locri, F.; Pucci, L.; Monte, M.D.; Casini, G. Lisosan G Protects the Retina from Neurovascular Damage in Experimental Diabetic Retinopathy. Nutrients 2018, 10, 1932.
Amato R, Rossino MG, Cammalleri M, Locri F, Pucci L, Monte MD, Casini G. Lisosan G Protects the Retina from Neurovascular Damage in Experimental Diabetic Retinopathy. Nutrients. 2018; 10(12):1932.Chicago/Turabian Style
Amato, Rosario; Rossino, Maria Grazia; Cammalleri, Maurizio; Locri, Filippo; Pucci, Laura; Monte, Massimo Dal; Casini, Giovanni. 2018. "Lisosan G Protects the Retina from Neurovascular Damage in Experimental Diabetic Retinopathy." Nutrients 10, no. 12: 1932.
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.