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The Role of Omega-3 Fatty Acids in the Setting of Coronary Artery Disease and COPD: A Review

Department of Internal Medicine II, Infectious Diseases, Pneumology, Rheumatology, Medical University of Innsbruck, 6020 Innsbruck, Austria
Department of Urology, Klinikum rechts der Isar, Technische Universität München, 81675 Munich, Germany
Author to whom correspondence should be addressed.
Authors with equal contribution.
Nutrients 2018, 10(12), 1864;
Received: 11 October 2018 / Revised: 9 November 2018 / Accepted: 22 November 2018 / Published: 2 December 2018
(This article belongs to the Special Issue Fatty Acids and Cardiometabolic Health)
PDF [1057 KB, uploaded 2 December 2018]


Chronic obstructive pulmonary disease (COPD) is a growing healthcare concern and will represent the third leading cause of death worldwide within the next decade. COPD is the result of a complex interaction between environmental factors, especially cigarette smoking, air pollution, and genetic preconditions, which result in persistent inflammation of the airways. There is growing evidence that the chronic inflammatory state, measurable by increased levels of circulating cytokines, chemokines, and acute phase proteins, may not be confined to the lungs. Cardiovascular disease (CVD) and especially coronary artery disease (CAD) are common comorbidities of COPD, and low-grade systemic inflammation plays a decisive role in its pathogenesis. Omega-3 polyunsaturated fatty acids (n-3 PUFAs) exert multiple functions in humans and are crucially involved in limiting and resolving inflammatory processes. n-3 PUFAs have been intensively studied for their ability to improve morbidity and mortality in patients with CVD and CAD. This review aims to summarize the current knowledge on the effects of n-3 PUFA on inflammation and its impact on CAD in COPD from a clinical perspective. View Full-Text
Keywords: omega 3; PUFA; n-3 PUFA; COPD; inflammation; coronary artery disease; ischemic heart disease; CAD; CHD omega 3; PUFA; n-3 PUFA; COPD; inflammation; coronary artery disease; ischemic heart disease; CAD; CHD

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Pizzini, A.; Lunger, L.; Sonnweber, T.; Weiss, G.; Tancevski, I. The Role of Omega-3 Fatty Acids in the Setting of Coronary Artery Disease and COPD: A Review. Nutrients 2018, 10, 1864.

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