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Nutrients 2018, 10(12), 1820; https://doi.org/10.3390/nu10121820

Cod Residual Protein Prevented Blood Pressure Increase in Zucker fa/fa Rats, Possibly by Inhibiting Activities of Angiotensin-Converting Enzyme and Renin

1
Dietary Protein Research Group, Department of Clinical Medicine, University of Bergen, 5021 Bergen, Norway
2
K. Halstensen AS, P.O. Box 103, 5399 Bekkjarvik, Norway
3
TripleNine Vedde AS, 6030 Langevåg, Norway
4
Nofima AS, P.B. 1425 Oasen, 5844 Bergen, Norway
5
Møreforsking Ålesund AS, P.O. Box 5075, 6021 Ålesund, Norway
6
Department of Clinical Science, University of Bergen, 5021 Bergen, Norway
*
Author to whom correspondence should be addressed.
Received: 1 November 2018 / Revised: 9 November 2018 / Accepted: 20 November 2018 / Published: 22 November 2018
(This article belongs to the Special Issue Nutrients Intake and Hypertension)
Full-Text   |   PDF [1933 KB, uploaded 22 November 2018]   |  

Abstract

Hypertension is the leading risk factor for cardiovascular disease, and prevention of high blood pressure through diet and lifestyle should be a preferred approach. High intake of fish is associated with lower blood pressure, possibly mediated through the proteins since peptides with angiotensin-converting enzyme (ACE) inhibiting capacities have been identified in fish skin, backbone, and fillet. The effects of cod meals made from residual materials and fillet on blood pressure were investigated in obese Zucker fa/fa rats which spontaneously develop high blood pressure. Rats were fed diets containing water-soluble (stickwater) or water-insoluble (presscake) fractions of protein-rich meals from cod residual materials (head, gut, backbone with muscle residuals, skin, trimmings) or fillet. Rats were fed diets containing 25% of total protein from cod meal and 75% of protein from casein, or casein as the sole protein source (control group) for four weeks. Results show that a diet containing residual presscake meal with high gut content prevented blood pressure increase, and this cod residual meal also showed the strongest in vitro inhibitions of ACE and renin activities. In conclusion, a diet containing water-insoluble proteins (presscake meal) with high gut content prevented increase in blood pressure in obese Zucker fa/fa rats. View Full-Text
Keywords: fish protein; fish meal; cod; rest raw material; hypertension fish protein; fish meal; cod; rest raw material; hypertension
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Vildmyren, I.; Drotningsvik, A.; Oterhals, Å.; Ween, O.; Halstensen, A.; Gudbrandsen, O.A. Cod Residual Protein Prevented Blood Pressure Increase in Zucker fa/fa Rats, Possibly by Inhibiting Activities of Angiotensin-Converting Enzyme and Renin. Nutrients 2018, 10, 1820.

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