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Descriptive Study of the Different Tools Used to Evaluate the Adherence to a Gluten-Free Diet in Celiac Disease Patients

Gastroenterology Unit, Hospital Universitario Central de Asturias (HUCA), CSIC, Avda. de Roma s/n, 33011 Oviedo, Spain
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Nutrients 2018, 10(11), 1777; https://doi.org/10.3390/nu10111777
Received: 15 October 2018 / Revised: 7 November 2018 / Accepted: 14 November 2018 / Published: 16 November 2018
(This article belongs to the Special Issue Gluten-Free Diet)
Celiac disease (CD) is a genetically conditioned autoimmune process that appears in susceptible people. It can affect people of any age, and slightly predominates in females. It has a fairly homogenous global distribution, with an average prevalence of 1–2%, the frequency having increased in recent decades. The only effective treatment is a strict and permanent gluten-free diet (GFD), although the level of compliance is poor, at about 50% of cases. To monitor the effectiveness of the GFD, several procedures involving various approaches are employed: (a) Periodic visits by expert Nutritionists; (b) Clinical follow-up; (c) Serological time controls of specific antibodies; (d) Serial endoscopies with collection of duodenal biopsies; (e) Use of structured questionnaires; and (f) Determination of gluten peptides derived from gluten in faeces and/or urine. All of these procedures are useful when applied, alone or in combination, depending on the cases. Some patients will only need to consult to their doctors, while others will require a multidisciplinary approach to assess their compliance with the GFD. In children, normalization of duodenal mucosa was achieved in 95% of cases within two years, while it is more delayed in adults, whose mucosa take longer time (3–5 years) to heal completely. View Full-Text
Keywords: celiac disease; gluten-free diet; effectiveness; adherence; nutritionists; clinic; serology; duodenal biopsies; structured questionnaires; peptides derived from gluten in faeces and urine celiac disease; gluten-free diet; effectiveness; adherence; nutritionists; clinic; serology; duodenal biopsies; structured questionnaires; peptides derived from gluten in faeces and urine
MDPI and ACS Style

Rodrigo, L.; Pérez-Martinez, I.; Lauret-Braña, E.; Suárez-González, A. Descriptive Study of the Different Tools Used to Evaluate the Adherence to a Gluten-Free Diet in Celiac Disease Patients. Nutrients 2018, 10, 1777.

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