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Nutrients 2018, 10(11), 1720; https://doi.org/10.3390/nu10111720

Bioavailability Study of Maqui Berry Extract in Healthy Subjects

1
BioTeSys GmbH, Schelztorstr. 54–56, 73728 Esslingen, Germany
2
Anklam Extrakt GmbH, Marienbergstr. 92, 90411 Nuremberg, Germany
*
Author to whom correspondence should be addressed.
Received: 12 October 2018 / Revised: 31 October 2018 / Accepted: 7 November 2018 / Published: 9 November 2018
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Abstract

Several health promoting effects have been reported for maqui berry, rich in anthocyanins. Direct effects of anthocyanins as well as bioactive metabolites might be involved. Within the study, bioavailability of a proprietary standardized maqui berry extract Delphinol® was investigated based on two selected anthocyanins (delphinidin-3-O-glucoside (DS) + cyanidin-3-O-sambubioside (CS)) and two breakdown products (protocatechuic acid (PCA) + gallic acid (GA)) after a single-dose supplementation in humans. Pharmacokinetic parameters were calculated from individual concentration time curves. In all 12 subjects a significant increase was noted in plasma values of DG and CS after intake of maqui berry extract. Maximum concentration of DG was observed after 1.0 ± 0.3 h and CS after 2.0 ± 1.1 h. Within 8 h, concentrations nearly returned to baseline levels. The results confirm a fast uptake and metabolism of the two selected key substances. Additionally, the phenolic acids GA and PCA were observed as breakdown products of anthocyanins. In summary, the study clearly confirms the bioavailability of maqui berry extract and its specific anthocyanin compounds and related breakdown products in healthy subjects. View Full-Text
Keywords: maqui berry extract; anthocyanins; human; delphinidin; bioavailability; anti-oxidative maqui berry extract; anthocyanins; human; delphinidin; bioavailability; anti-oxidative
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Schön, C.; Wacker, R.; Micka, A.; Steudle, J.; Lang, S.; Bonnländer, B. Bioavailability Study of Maqui Berry Extract in Healthy Subjects. Nutrients 2018, 10, 1720.

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