Next Article in Journal
Almond Allergy: An Overview on Prevalence, Thresholds, Regulations and Allergen Detection
Next Article in Special Issue
Mood Disorders and Gluten: It’s Not All in Your Mind! A Systematic Review with Meta-Analysis
Previous Article in Journal
Lifestyle Interventions in Overweight and Obese Pregnant or Postpartum Women for Postpartum Weight Management: A Systematic Review of the Literature
Previous Article in Special Issue
The Handbook of Minerals on a Gluten-Free Diet
Article Menu

Export Article

Open AccessReview
Nutrients 2018, 10(11), 1705;

Motility Disorders in Celiac Disease and Non-Celiac Gluten Sensitivity: The Impact of a Gluten-Free Diet

Gastroenteorlogy Unit, Brotzu Hospital, 09121 Cagliari, Italy
Gastroenterology Unit, University of Cagliari, 09042 Monserrato, Italy
Author to whom correspondence should be addressed.
Received: 25 September 2018 / Revised: 21 October 2018 / Accepted: 5 November 2018 / Published: 7 November 2018
(This article belongs to the Special Issue Gluten-Free Diet)
Full-Text   |   PDF [204 KB, uploaded 7 November 2018]


Background: There is evidence that digestive motor disorders are frequently present in untreated celiac disease (CD) patients. Similarly, non-celiac gluten sensitivity (NCGS) can be associated with gut motor disorders. In both cases, gut dysmotility can improve or be completely reversed with a gluten-free diet (GFD). Methods: A literature search for motility disorders in CD and NCGS patients was carried out using the online databases PubMed, Medline and Cochrane. Results: Esophageal, gastric, small bowel and gallbladder motor disorders are common in both children and adults with CD. Although the clinical consequences of these disorders are not clearly defined, gastric dysfunction could affect drug absorption and metabolism in the thyroid and neurological conditions associated with CD. The impact of a GFD on motility disorders is, however, controversial. No systematic studies are available on NCGS. NCGS frequently overlaps with irritable bowel syndrome (IBS) and similar pathophysiological mechanisms may be hypothesized. Conclusions: Mucosal damage may affect gut motility in untreated CD through perturbation of hormonal and neuro-immunomodulatory regulation. A persistent low-grade mucosal inflammation could explain the cases of persistent motor disorders despite a GFD. Further studies are needed to definitely assess the role of gut motor disorders in NCGS. View Full-Text
Keywords: celiac disease; non-celiac gluten sensitivity; gut motility; gluten-free diet celiac disease; non-celiac gluten sensitivity; gut motility; gluten-free diet
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

Share & Cite This Article

MDPI and ACS Style

Usai-Satta, P.; Oppia, F.; Lai, M.; Cabras, F. Motility Disorders in Celiac Disease and Non-Celiac Gluten Sensitivity: The Impact of a Gluten-Free Diet. Nutrients 2018, 10, 1705.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Nutrients EISSN 2072-6643 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top