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Nutrients 2018, 10(11), 1642; https://doi.org/10.3390/nu10111642

Impact of Circulating Triglycerides Concentration on Atherosclerotic Disease Status in Middle-Aged Saudi Arabian Dwellers

1
Department of Health Professions, Faculty of Health, Psychology and Social Care, Manchester Metropolitan University, Manchester M15 6BG, UK
2
Department of Exercise & Sport Science, Manchester Metropolitan University, Crewe, Cheshire CW1 5DU, UK
*
Author to whom correspondence should be addressed.
Received: 14 October 2018 / Revised: 26 October 2018 / Accepted: 27 October 2018 / Published: 2 November 2018
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Abstract

A number of food micronutrients are reported to influence markers of cardio-metabolic health. There is an expectation that there may be an optimal endocrine profile, with triglycerides as a key factor, which may help minimise atherosclerotic disease and associated risk factors. This study involved 84 participants aged (mean ± SD) 48.2 ± 8.3 years from both sexes segregated into n = 30 controls, n = 25 at-risk, and n = 29 diagnosed with atherosclerosis, including 20 participants using statins. Atherosclerosis status and risk factors were assessed using a combination of clinical records, C-reactive protein (CRP), blood glucose (FBG), lipids profiles, vascular structural and functional characteristics (including carotid-radial pulse wave velocity (CR-PWV), central systolic blood pressure (C-SBP), peripheral systolic blood pressure (P-SBP), peripheral diastolic blood pressure (P-DBP), carotid intima-media thickness (IMT), and carotid artery inter-adventitial diameter (IAD)). There was a significant difference in triglycerides (TG) levels between the clinical groups (p < 0.05) and between the users and non-users of statin (p < 0.001). Significant associations were distinguished between TG and CRP, FBG, high-density lipoprotein (HDL), C-SBP, P-SBP, P-DBP, CR-PWV, heart rate (HR), and body weight in the pooled sample (p < 0.05). In non-users of statin, TG was associated with C-SBP, P-SBP, P-DBP, and HR. In sub-clinical groups, TG was also associated with most of the blood markers. After controlling for statin use, composite z-score analysis revealed 48%, 2%, and 0% differences in in vivo vascular phenotype between high and low TG subgroups in controls, at-risk, and diagnosed atherosclerosis groups, respectively. Thus, TG levels seem to be good indicators for incidence and risk factors of atherosclerosis. View Full-Text
Keywords: triglycerides; atherosclerosis; cardiometabolic health; central blood pressure; peripheral blood pressure; composite z-score triglycerides; atherosclerosis; cardiometabolic health; central blood pressure; peripheral blood pressure; composite z-score
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Azhar, W.; Buczkowski, B.; Smith, C.; Onambele-Pearson, G. Impact of Circulating Triglycerides Concentration on Atherosclerotic Disease Status in Middle-Aged Saudi Arabian Dwellers. Nutrients 2018, 10, 1642.

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