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Nutrients 2018, 10(11), 1614;

The Role of Vitamin E in Immunity

Department of Food and Nutrition, College of Human Ecology, Seoul National University, Seoul 08826, Korea
Research Institute of Human Ecology, Seoul National University, Seoul 08826, Korea
Author to whom correspondence should be addressed.
Received: 30 September 2018 / Revised: 23 October 2018 / Accepted: 29 October 2018 / Published: 1 November 2018
(This article belongs to the Special Issue Diet and Immune Function)
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Vitamin E is a fat-soluble antioxidant that can protect the polyunsaturated fatty acids (PUFAs) in the membrane from oxidation, regulate the production of reactive oxygen species (ROS) and reactive nitrogen species (RNS), and modulate signal transduction. Immunomodulatory effects of vitamin E have been observed in animal and human models under normal and disease conditions. With advances in understating of the development, function, and regulation of dendritic cells (DCs), macrophages, natural killer (NK) cells, T cells, and B cells, recent studies have focused on vitamin E’s effects on specific immune cells. This review will summarize the immunological changes observed with vitamin E intervention in animals and humans, and then describe the cell-specific effects of vitamin E in order to understand the mechanisms of immunomodulation and implications of vitamin E for immunological diseases. View Full-Text
Keywords: vitamin E; macrophages; T cells; dendritic cells; immunomodulation; infection vitamin E; macrophages; T cells; dendritic cells; immunomodulation; infection

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Lee, G.Y.; Han, S.N. The Role of Vitamin E in Immunity. Nutrients 2018, 10, 1614.

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