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Open AccessFeature PaperArticle

Peripheral Blood Mononuclear Cells Antioxidant Adaptations to Regular Physical Activity in Elderly People

1
Research Group on Community Nutrition and Oxidative Stress & Laboratory of Physical Activity Science, University of Balearic Islands, 07122, Palma de Mallorca, Spain
2
CIBEROBN, Instituto de Salud Carlos III (ISCIII), 28029 Madrid, Spain
3
Departamento de Nutrición y Dietética, Facultad de Farmacia, Universidad de Concepción, 4070386 Concepción, Chile
*
Author to whom correspondence should be addressed.
Nutrients 2018, 10(10), 1555; https://doi.org/10.3390/nu10101555
Received: 18 September 2018 / Revised: 15 October 2018 / Accepted: 18 October 2018 / Published: 20 October 2018
(This article belongs to the Special Issue Antioxidant Intake in Older Adults and Elderly People)
Regular physical activity prescription is a key point for healthy aging and chronic disease management and prevention. Our aim was to evaluate the antioxidant defense system and the mitochondrial status in peripheral blood mononuclear cells (PBMCs) and the level of oxidative damage in plasma in active, intermediate and inactive elderly. In total, 127 healthy men and women >55 years old participated in the study and were classified according on their level of declared physical activity. A more active lifestyle was accompanied by lower weight, fat mass and body mass index when compared to a more sedentary life-style. Active participants exhibited lower circulating PBMCs than inactive peers. Participants who reported higher levels of exercise had increased antioxidant protein levels when compared to more sedentary partakers. Carbonylated protein levels exhibited similar behavior, accompanied by a significant raise in expression of cytochrome c oxidase subunit IV in PBMCs. No significant changes were found in the activities of antioxidant enzymes and in the expression of structural (MitND5) and mitochondrial dynamic-related (PGC1α and Mitofusins1/2.) proteins. Active lifestyle and daily activities exert beneficial effects on body composition and it enhances the antioxidant defenses and oxidative metabolism capabilities in PBMCs from healthy elderly. View Full-Text
Keywords: active lifestyle; antioxidants; daily habits; elderly; healthy aging; mitochondria; PBMCs; ROS active lifestyle; antioxidants; daily habits; elderly; healthy aging; mitochondria; PBMCs; ROS
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Busquets-Cortés, C.; Capó, X.; Bibiloni, M.D.M.; Martorell, M.; Ferrer, M.D.; Argelich, E.; Bouzas, C.; Carreres, S.; Tur, J.A.; Pons, A.; Sureda, A. Peripheral Blood Mononuclear Cells Antioxidant Adaptations to Regular Physical Activity in Elderly People. Nutrients 2018, 10, 1555.

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